CAJ | 학술논문

喹诺酮类药物（Quinolones,Qs）是一类合成广谱抗菌药，自20世纪60年代萘啶酸被运用于临床医学以后，同时喹诺酮类药物的耐药问题便接踵而至，这使得喹诺酮类药物成为开发最活跃，更新换代最迅速的药物。由于其具有抗菌谱广，抗菌活性强，与常用抗菌药物无交叉耐药，已成为临床治疗感染性疾病的主要药物之一。然而，随着喹诺酮类药物在人医和兽医临床的广泛、长期、大量盲目滥用，使得其耐药性近年呈蔓延增长趋势，耐药程度越来越重，耐药菌株越来越多。其中，大场杆菌对喹诺酮类药物的耐药性问题是当前国内外研究的热点。本文综述了大肠杆菌对氟喹诺酮类药物耐药现状及特点，并分析了其耐药机制，简要综述了减缓耐药性的一些防治策略。
규낙동류약물（Quinolones,Qs）시일류합성엄보항균약，자20세기60년대내정산피운용우림상의학이후，동시규낙동류약물적내약문제편접종이지，저사득규낙동류약물성위개발최활약，경신환대최신속적약물。유우기구유항균보엄，항균활성강，여상용항균약물무교차내약，이성위림상치료감염성질병적주요약물지일。연이，수착규낙동류약물재인의화수의림상적엄범、장기、대량맹목람용，사득기내약성근년정만연증장추세，내약정도월래월중，내약균주월래월다。기중，대장간균대규낙동류약물적내약성문제시당전국내외연구적열점。본문종술료대장간균대불규낙동류약물내약현상급특점，병분석료기내약궤제，간요종술료감완내약성적일사방치책략。
The Quinolones is a kind of synthetic wide table antimicrobial, Dixiben was applied to clinic medicine since the sixties of the 20th century the question of resistance of Quinolones appeared at the same time that made Quinolones become and develop the most active, update the fastest medicine. Because it has antibacterial wide tables, the antibacterial activity is strong and have not been cross resistance with daily antibacterial medicines, have become one of the clinical main medicines to treat the infective disease. However, as the Quinolones abuse in people and veterinarian's medicine and clinical y extensively and long-termly and in a large amount led to bacterias resistance to quinolones show a tendency to spread and increase in recent years, resistance degree to be more and more heavy , resistance of strains are more and more many. Quinolone resistance in Escherichia coli is a focus studied both at home and abroad at present . The review focuses on prevalence and resistance status of E.coli in Quinolones, the mechanism of Quinolones resistance in E.coli and provides some prevention and cure strategies slow-down dug-resistance.