上海医药
上海醫藥
상해의약
SHANGHAI MEDICAL & PHARMACEUTICAL JOURNAL
2014年
3期
22-25
,共4页
2型糖尿病%中心性肥胖%胰岛素抵抗%代谢综合征%益气化聚方
2型糖尿病%中心性肥胖%胰島素牴抗%代謝綜閤徵%益氣化聚方
2형당뇨병%중심성비반%이도소저항%대사종합정%익기화취방
type 2 diabetes mellitus%central obesity%insulin resistance%metabolic syndrome%Yiqi Huaju herb formula
目的：观察在常规西医治疗的基础上联合益气化聚方治疗伴中心性肥胖2型糖尿病的临床疗效。方法：将伴中心性肥胖2型糖尿病患者48例随机分为治疗（益气化聚方联合常规西药）组26例和对照（安慰剂联合常规西药）组22例，两组疗程均为12周。观察两组治疗前后的体重指数、腰围、腰臀比、空腹血糖、餐后2 h血糖、空腹胰岛素、糖化血红蛋白A1C和胰岛素抵抗指数等指标。结果：治疗组治疗前后的体重指数、腰围和腰臀比明显下降，而对照组治疗前后的体重指数、腰围和腰臀比无统计学差异。两组治疗后相比，治疗组的餐后2h血糖、空腹胰岛素、糖化血红蛋白A1C水平和胰岛素抵抗指数均明显低于对照组。结论：在常规西药治疗的基础上加用益气化聚方能较单用常规西药治疗明显改善伴有中心性肥胖2型糖尿病患者的胰岛素抵抗、纠正中心性肥胖，并进一步改善糖代谢紊乱。
目的：觀察在常規西醫治療的基礎上聯閤益氣化聚方治療伴中心性肥胖2型糖尿病的臨床療效。方法：將伴中心性肥胖2型糖尿病患者48例隨機分為治療（益氣化聚方聯閤常規西藥）組26例和對照（安慰劑聯閤常規西藥）組22例，兩組療程均為12週。觀察兩組治療前後的體重指數、腰圍、腰臀比、空腹血糖、餐後2 h血糖、空腹胰島素、糖化血紅蛋白A1C和胰島素牴抗指數等指標。結果：治療組治療前後的體重指數、腰圍和腰臀比明顯下降，而對照組治療前後的體重指數、腰圍和腰臀比無統計學差異。兩組治療後相比，治療組的餐後2h血糖、空腹胰島素、糖化血紅蛋白A1C水平和胰島素牴抗指數均明顯低于對照組。結論：在常規西藥治療的基礎上加用益氣化聚方能較單用常規西藥治療明顯改善伴有中心性肥胖2型糖尿病患者的胰島素牴抗、糾正中心性肥胖，併進一步改善糖代謝紊亂。
목적：관찰재상규서의치료적기출상연합익기화취방치료반중심성비반2형당뇨병적림상료효。방법：장반중심성비반2형당뇨병환자48례수궤분위치료（익기화취방연합상규서약）조26례화대조（안위제연합상규서약）조22례，량조료정균위12주。관찰량조치료전후적체중지수、요위、요둔비、공복혈당、찬후2 h혈당、공복이도소、당화혈홍단백A1C화이도소저항지수등지표。결과：치료조치료전후적체중지수、요위화요둔비명현하강，이대조조치료전후적체중지수、요위화요둔비무통계학차이。량조치료후상비，치료조적찬후2h혈당、공복이도소、당화혈홍단백A1C수평화이도소저항지수균명현저우대조조。결론：재상규서약치료적기출상가용익기화취방능교단용상규서약치료명현개선반유중심성비반2형당뇨병환자적이도소저항、규정중심성비반，병진일보개선당대사문란。
Objective:To observe the the effects of Yiqi Huaju herb formula on type 2 diabetes mellitus subjects with central obesity. Methods:Forty-eight cases of type 2 diabetes mellitus patients with central obesity were randomly divided into either a treatment group (Yiqi Huaju herb formula treatment in combination with western medicine) or a control group (placebo in combination with western medicine). Both groups were administered for 12 weeks. Various indications such as body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPPG), fasting plasma insulin (FPI), glycosylated hemoglobin A1C (HbA1C), homeostatic model assessment for insulin resistance (HOMA-IR) were observed before and after treatment. Results:BMI, WC and WHR were signiifcantly decreased in treatment group compared with the control group. The parameters such as FPG, 2hPPG, HbA1C, HOMA-IR were also signiifcantly decreased in both groups, however, the better effects were obtained from the treatment group. Conclusion:Combination of Yiqi Huaju herb formula with western medicine can effectively improve insulin resistance and central obesity, and further improve the disorder of glucose metabolism.
