CAJ | 학술논문

目的：探讨手足口病（HFMD）患儿机体免疫功能的变化。方法将236例HFMD患儿分为3组，肠道病毒71型（EV71）感染组（EV71组）99例，柯萨奇病毒A组16型感染110例（CoxA16组），有严重合并症的患儿27例纳入重症组。另将24例疝气患儿纳入对照组。检测并比较患儿外周血各类淋巴细胞亚群百分比的差异。结果HFMD患儿CD3＋、CD3＋CD4＋亚群百分比较对照组下降，且重症患儿更为明显（P＜0．05）。CD3＋ CD8＋亚群百分比仅重症组低于对照组（P＜0．05）。重症组CD3-CD16＋ CD56＋亚群百分比较EV71组、CoxA16组和对照组升高（P＜0．05）。HFMD患儿CD3-CD19＋、CD19＋CD23＋亚群百分比高于对照组，且EV71组升高更明显（P＜0．05）。HFMD患儿CD4＋CD25＋ T亚群百分比高于对照组（P＜0．05）。结论 HFMD患儿存在不同程度的免疫功能紊乱；CD3＋、CD3＋CD8＋和CD3-CD16＋CD56＋亚群百分比检测可用于监测HFMD患儿病情。
목적：탐토수족구병（HFMD）환인궤체면역공능적변화。방법장236례HFMD환인분위3조，장도병독71형（EV71）감염조（EV71조）99례，가살기병독A조16형감염110례（CoxA16조），유엄중합병증적환인27례납입중증조。령장24례산기환인납입대조조。검측병비교환인외주혈각류림파세포아군백분비적차이。결과HFMD환인CD3＋、CD3＋CD4＋아군백분비교대조조하강，차중증환인경위명현（P＜0．05）。CD3＋ CD8＋아군백분비부중증조저우대조조（P＜0．05）。중증조CD3-CD16＋ CD56＋아군백분비교EV71조、CoxA16조화대조조승고（P＜0．05）。HFMD환인CD3-CD19＋、CD19＋CD23＋아군백분비고우대조조，차EV71조승고경명현（P＜0．05）。HFMD환인CD4＋CD25＋ T아군백분비고우대조조（P＜0．05）。결론 HFMD환인존재불동정도적면역공능문란；CD3＋、CD3＋CD8＋화CD3-CD16＋CD56＋아군백분비검측가용우감측HFMD환인병정。
Objective To investigate the change of immune function in children with hand-foot-mouth disease (HFMD) .Methods A total of 236 children with HFMD were divided into three groups ,including 99 cases with en-terovirus 71 type infection (EV71 group) ,110 cases with Coxsackie virus A group 16 type infection (CoxA16 group) and 27 cases with severe complications (severe group) .The other 24 children with indirect inguinal hernia were en-rolled as control group .Percentages of lymphocyte subsets in peripheral blood were detected and compared between each group .Results CD3+ and CD3+ CD4+ subsets decreased obviously in HFMD children ,and those in severe group were lower (P<0 .05) .CD3+ CD8+ subsets in severe group decreased (P<0 .05) .CD3-CD16+ CD56+ sub-sets in severe group increased ,compared with EV71 group ,CoxA16 group and control group ( P< 0 .05 ) .CD3-CD19+ and CD19+CD23+ subsets in severe group ,EV71 group and CoxA16 group increased ,compared with control group ,and those in EV71 group were higher (P<0 .05) .CD4+CD25+ subsets in severe group ,EV71 group and Cox-A16 group increased ,compared with control group(P<0 .05) .Conclusion Immune function in children with HFMD might be disordered .Detection of CD3+ ,CD3+CD8+ and CD3-CD16+CD56+ subsets could be useful for the monito-ring of pathogenetic condition in children with HFMD .