中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2014年
4期
1-2
,共2页
新生儿缺氧缺血性脑病%电解质%血糖
新生兒缺氧缺血性腦病%電解質%血糖
신생인결양결혈성뇌병%전해질%혈당
Hypoxic-ischemic encephalopathy%Electrolyte%Blood glucose
目的：探讨新生儿缺氧缺血性脑病(HIE)的血清生化，包括钾、钠、氯、钙和葡萄糖的变化及其临床意义。方法：对165例不同程度的HIE患儿(HIE组)进行血液中钾、钠、氯、钙和葡萄糖检测，并与35例正常新生儿(对照组)血液中上述指标进行比较。结果：HIE组与对照组血清电解质比较，血钠和血钙明显降低，血钾升高，差异有统计学意义(P<0.05)；两组氯离子比较，差异无统计学意义(P>0.05)；不同程度HIE中电解质钠和钙降低程度与HIE的分度有明显的正相关关系，相关系数分别为0.841(P<0.05)和0.654(P<0.05)；轻中度HIE患儿以低血糖为主，随着HIE临床分度的增加，高血糖发生率增高。结论：HIE患儿可出现低钠、低钙和高钾血症及糖代谢紊乱，HIE程度越重，血钠、血钙水平越低，且彼此间呈正相关，而高血糖的发生率越高，提示血钠、血钙和血糖对判断HIE病情严重程度及预后具有一定的临床意义。
目的：探討新生兒缺氧缺血性腦病(HIE)的血清生化，包括鉀、鈉、氯、鈣和葡萄糖的變化及其臨床意義。方法：對165例不同程度的HIE患兒(HIE組)進行血液中鉀、鈉、氯、鈣和葡萄糖檢測，併與35例正常新生兒(對照組)血液中上述指標進行比較。結果：HIE組與對照組血清電解質比較，血鈉和血鈣明顯降低，血鉀升高，差異有統計學意義(P<0.05)；兩組氯離子比較，差異無統計學意義(P>0.05)；不同程度HIE中電解質鈉和鈣降低程度與HIE的分度有明顯的正相關關繫，相關繫數分彆為0.841(P<0.05)和0.654(P<0.05)；輕中度HIE患兒以低血糖為主，隨著HIE臨床分度的增加，高血糖髮生率增高。結論：HIE患兒可齣現低鈉、低鈣和高鉀血癥及糖代謝紊亂，HIE程度越重，血鈉、血鈣水平越低，且彼此間呈正相關，而高血糖的髮生率越高，提示血鈉、血鈣和血糖對判斷HIE病情嚴重程度及預後具有一定的臨床意義。
목적：탐토신생인결양결혈성뇌병(HIE)적혈청생화，포괄갑、납、록、개화포도당적변화급기림상의의。방법：대165례불동정도적HIE환인(HIE조)진행혈액중갑、납、록、개화포도당검측，병여35례정상신생인(대조조)혈액중상술지표진행비교。결과：HIE조여대조조혈청전해질비교，혈납화혈개명현강저，혈갑승고，차이유통계학의의(P<0.05)；량조록리자비교，차이무통계학의의(P>0.05)；불동정도HIE중전해질납화개강저정도여HIE적분도유명현적정상관관계，상관계수분별위0.841(P<0.05)화0.654(P<0.05)；경중도HIE환인이저혈당위주，수착HIE림상분도적증가，고혈당발생솔증고。결론：HIE환인가출현저납、저개화고갑혈증급당대사문란，HIE정도월중，혈납、혈개수평월저，차피차간정정상관，이고혈당적발생솔월고，제시혈납、혈개화혈당대판단HIE병정엄중정도급예후구유일정적림상의의。
Objective:To explore the change and their clinical significance of K+,Na+,Cl-,Ca2+ and glucose in serum of hypoxia-ischemic encephalopathy(HIE).Method:Testing 165 serum samples from HIE and 35 serum samples from normal neonatal for K+,Na+,Cl-,Ca2+,glucose in order to compare with each other.Result:Na+and Ca2+in serum decrease obviously and K+increased in HIE group,the difference between two groups was statistically significant(P<0.05);But the Cl-level had no significant change(P>0.05).Different degree of HIE and the decrease of Na+and Ca2+had significantly positive correlation and r=0.841(P<0.05),0.654(P<0.05).Hypoglycemia much more happened in mild and moderate HIE,the incidence of hyperglycemia increased with the clinic degree of HIE.Conclusion:Children with HIE can appear low level of Ca2+,Na+and high level of K+and glucose metabolic disorder.The more serious of HIE degree,the lower are Ca2+,Na+in blood,which are significantly positive correlation with increased incidence of hyperglycemia.Above results indicate that the K+,Na+,Ca2+and glucose in blood have certain clinical significance to justice the degree of HIE and its prognosis.
