中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
4期
34-35,36
,共3页
焦亚莉%杨丽娟%朱蕾%陈蕾%霍亚平
焦亞莉%楊麗娟%硃蕾%陳蕾%霍亞平
초아리%양려연%주뢰%진뢰%곽아평
大肠肿瘤%血管内皮生长因子%微血管密度%Ki-67
大腸腫瘤%血管內皮生長因子%微血管密度%Ki-67
대장종류%혈관내피생장인자%미혈관밀도%Ki-67
Colorectal neoplasms%VEGF%MVD%Ki-67
目的：探讨大肠癌组织VEGF、Ki-67的表达和微血管密度（MVD）及其临床意义。方法：应用免疫组化SP法检测60例大肠癌组织中VEGF、Ki-67的表达和MVD，并分析其临床特征及相关性。结果：大肠癌VEGF、Ki-67的阳性表达率分别为76.7%、73.2%，明显高于癌旁肠组织的35.0%、20.1%。两者比较差异均有统计学意义（P<0.05）；VEGF阳性率在有/无淋巴结转移的大肠癌中差异显著（P<0.05）；VEGF阳性表达组MVD值显著高于阴性组（P<0.05）。结论：VEGF与大肠癌的发生、发展和转移密切相关，提示阻断VEGF通路将对大肠癌的治疗提供新的靶点。Ki-67是肿瘤良恶性鉴别、提示预后的重要指标。
目的：探討大腸癌組織VEGF、Ki-67的錶達和微血管密度（MVD）及其臨床意義。方法：應用免疫組化SP法檢測60例大腸癌組織中VEGF、Ki-67的錶達和MVD，併分析其臨床特徵及相關性。結果：大腸癌VEGF、Ki-67的暘性錶達率分彆為76.7%、73.2%，明顯高于癌徬腸組織的35.0%、20.1%。兩者比較差異均有統計學意義（P<0.05）；VEGF暘性率在有/無淋巴結轉移的大腸癌中差異顯著（P<0.05）；VEGF暘性錶達組MVD值顯著高于陰性組（P<0.05）。結論：VEGF與大腸癌的髮生、髮展和轉移密切相關，提示阻斷VEGF通路將對大腸癌的治療提供新的靶點。Ki-67是腫瘤良噁性鑒彆、提示預後的重要指標。
목적：탐토대장암조직VEGF、Ki-67적표체화미혈관밀도（MVD）급기림상의의。방법：응용면역조화SP법검측60례대장암조직중VEGF、Ki-67적표체화MVD，병분석기림상특정급상관성。결과：대장암VEGF、Ki-67적양성표체솔분별위76.7%、73.2%，명현고우암방장조직적35.0%、20.1%。량자비교차이균유통계학의의（P<0.05）；VEGF양성솔재유/무림파결전이적대장암중차이현저（P<0.05）；VEGF양성표체조MVD치현저고우음성조（P<0.05）。결론：VEGF여대장암적발생、발전화전이밀절상관，제시조단VEGF통로장대대장암적치료제공신적파점。Ki-67시종류량악성감별、제시예후적중요지표。
Objective:To investigate effect of the expression of vascular endothelial growth factor(VEGF),Ki-67 and on intratumour microvessel density(MVD)in colorectal carcinoma tissues. Method:The immunohistochemical(SP method)was used to detect the expression of VEGF, Ki-67 and MVD in 60 cases of colorectal carcinomas,analyzed the clinical pathological characteristics and correlation. Result:The positive expression rates of VEGF and Ki-67 of colorectal carcinoma were 76.7%and 73.2%,which were higher than that in adjacent non-neoplastic tissue(35.0%and 20.1%)(P<0.05). The expression of VEGF in colorectal carcinoma was correlated with lymph node metastasis(P<0.05). The expression of VEGF was correlated with MVD(P<0.05). Conclusion:VEGF might have important significance in the carcinogenesis,progression and metastasis of colorectal carcinoma,and VEGF might be as a potentially useful target for therapeutic intervention in colorectal carcinoma patients. Ki-67 plays an important value in differential diagnosis and prognosis of the tumour.
