CAJ | 학술논문

目的：探讨惠州地区胆管癌发生的相关危险因子。方法：采用多中心的医院人群病例对照研究。病例组：收集惠州市中心人民医院及博罗县人民医院2007年1月-2012年12月106例胆管癌患者的临床资料。对照组：按照同性别、同民族、年龄相差±5岁，居住在惠州，1：1配比106例同期在以上两所医院住院的非肿瘤患者。统计两组的饮酒史、吸烟史、饮食习惯、高血压病、糖尿病、高脂血症、HBsAg（+）、胆囊结石或胆囊切除病史、胆管结石等资料，并进行单因子及多因子Logistic分析。结果：病例组与对照组的饮食习惯差异有统计学意义（P<0.05）。病例组高脂血症、HBsAg（+）、胆管结石或胆囊切除史、胆管结石的发生率均高于对照组（P<0.05）；高脂血症、胆管结石调整OR（95%CI）分别为12.8（5.3~30.6）、18.2（1.7~192.9）。结论：胆管结石、高脂血症是惠州地区胆管癌发生的危险因子。
목적：탐토혜주지구담관암발생적상관위험인자。방법：채용다중심적의원인군병례대조연구。병례조：수집혜주시중심인민의원급박라현인민의원2007년1월-2012년12월106례담관암환자적림상자료。대조조：안조동성별、동민족、년령상차±5세，거주재혜주，1：1배비106례동기재이상량소의원주원적비종류환자。통계량조적음주사、흡연사、음식습관、고혈압병、당뇨병、고지혈증、HBsAg（+）、담낭결석혹담낭절제병사、담관결석등자료，병진행단인자급다인자Logistic분석。결과：병례조여대조조적음식습관차이유통계학의의（P<0.05）。병례조고지혈증、HBsAg（+）、담관결석혹담낭절제사、담관결석적발생솔균고우대조조（P<0.05）；고지혈증、담관결석조정OR（95%CI）분별위12.8（5.3~30.6）、18.2（1.7~192.9）。결론：담관결석、고지혈증시혜주지구담관암발생적위험인자。
Objective:To explore the risk factors of cholangiocarcinoma in Huizhou district. Method:One-hundred and six patients suffering cholangiocarcinoma matched by sex,nationality,age(+/-5years),hospital admittance and place of residence were interviewed in Huizhou district between 2007 and 2012,and their 9 information(dietary habit,smoking,drinking,hypertension,diabetes,hyperlipemia,HBsAg(+),gallbladder stone or cholecystectomy,cholangiolithiasis)were collected. Odds ratios(OR)and 95%confidence intervals(CI)were calculated for each risk factor. Result:Univariate analysis showed that the risk factors for development of cholangiocarcinoma were hyperlipemia,HBsAg(+),gallbladder stone or cholecystectomy,cholangiolithiasis,and also showed that the factor for decrease in risk among individuals who consume more sea food(P<0.05). In multivariate stepwise logistic regression analysis,hyperlipemia(OR=12.8,95%CI:5.3-30.6)and cholangiolithiasis(OR=18.2,95%CI:1.7-192.9) were independent factors(P<0.05). Conclusion:This finding suggest that hyperlipemia and cholangiolithiasis are the risk factors for development of cholangiocarcinoma in Huizhou district.