中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
4期
6-7,8
,共3页
地佐辛%氟比洛芬酯%术后镇痛%腹腔镜手术
地佐辛%氟比洛芬酯%術後鎮痛%腹腔鏡手術
지좌신%불비락분지%술후진통%복강경수술
Dezocine%Flurbiprofen%Postoperative analgesia%Laparoscopic surgery
目的：观察地佐辛复合氟比洛芬酯用于腹腔镜术后患者静脉自控镇痛（PCIA）的效果。方法：普外科择期行腹腔镜手术患者80例，随机分为地佐辛组（D组）和地佐辛复合氟比洛芬酯组（DF组），每组40例。术后均行PCIA。镇痛药物配方D组：地佐辛1.0 mg/kg+托烷司琼5 mg+0.9%生理盐水=100 mL；DF组：地佐辛0.8 mg/kg+氟比洛芬酯2 mg/kg+托烷司琼5 mg+0.9%生理盐水=100 mL。观察并记录术后2、4、8、12、24、48 h患者安静状态和90°翻身时镇痛效果（VAS评分）和各时点镇静效果（Ramsay评分），各时间段PCIA按压次数和不良反应发生情况及生命体征变化。结果：两组患者均获得良好的镇痛效果，两组各时点安静状态下VAS评分和Ramsay评分差异均无统计学意义（P>0.05）。但各时点90：翻身时DF组VAS评分明显优于D组，两组比较差异均有统计学意义（P<0.05）。各时段PCIA按压次数无明显差异；DF组不良反应的发生率明显低于D组。结论：两种方法均可有效用于普外科腹腔镜术后镇痛。与单独使用地佐辛相比，地佐辛复合氟比洛芬酯对术后运动痛疗效更好，且不良反应少。
目的：觀察地佐辛複閤氟比洛芬酯用于腹腔鏡術後患者靜脈自控鎮痛（PCIA）的效果。方法：普外科擇期行腹腔鏡手術患者80例，隨機分為地佐辛組（D組）和地佐辛複閤氟比洛芬酯組（DF組），每組40例。術後均行PCIA。鎮痛藥物配方D組：地佐辛1.0 mg/kg+託烷司瓊5 mg+0.9%生理鹽水=100 mL；DF組：地佐辛0.8 mg/kg+氟比洛芬酯2 mg/kg+託烷司瓊5 mg+0.9%生理鹽水=100 mL。觀察併記錄術後2、4、8、12、24、48 h患者安靜狀態和90°翻身時鎮痛效果（VAS評分）和各時點鎮靜效果（Ramsay評分），各時間段PCIA按壓次數和不良反應髮生情況及生命體徵變化。結果：兩組患者均穫得良好的鎮痛效果，兩組各時點安靜狀態下VAS評分和Ramsay評分差異均無統計學意義（P>0.05）。但各時點90：翻身時DF組VAS評分明顯優于D組，兩組比較差異均有統計學意義（P<0.05）。各時段PCIA按壓次數無明顯差異；DF組不良反應的髮生率明顯低于D組。結論：兩種方法均可有效用于普外科腹腔鏡術後鎮痛。與單獨使用地佐辛相比，地佐辛複閤氟比洛芬酯對術後運動痛療效更好，且不良反應少。
목적：관찰지좌신복합불비락분지용우복강경술후환자정맥자공진통（PCIA）적효과。방법：보외과택기행복강경수술환자80례，수궤분위지좌신조（D조）화지좌신복합불비락분지조（DF조），매조40례。술후균행PCIA。진통약물배방D조：지좌신1.0 mg/kg+탁완사경5 mg+0.9%생리염수=100 mL；DF조：지좌신0.8 mg/kg+불비락분지2 mg/kg+탁완사경5 mg+0.9%생리염수=100 mL。관찰병기록술후2、4、8、12、24、48 h환자안정상태화90°번신시진통효과（VAS평분）화각시점진정효과（Ramsay평분），각시간단PCIA안압차수화불량반응발생정황급생명체정변화。결과：량조환자균획득량호적진통효과，량조각시점안정상태하VAS평분화Ramsay평분차이균무통계학의의（P>0.05）。단각시점90：번신시DF조VAS평분명현우우D조，량조비교차이균유통계학의의（P<0.05）。각시단PCIA안압차수무명현차이；DF조불량반응적발생솔명현저우D조。결론：량충방법균가유효용우보외과복강경술후진통。여단독사용지좌신상비，지좌신복합불비락분지대술후운동통료효경호，차불량반응소。
Objective:To investigate the effects of dezocine combined with flurbiprofen for patients control intravenous analgesia(PCIA)after laparoscopic surgeries. Method:Eighty patients scheduled for selective laparoscopic surgeries were randomly divided into dezocine group(group D) and dezocine combined with flurbiprofen group(group DF),each group of 40 cases. Patients in group D were given dezocine 1.0 mg/kg+Tropisetron 5 mg+0.9%Nacl=100 mL;patients in group DF were given dezocine 0.8 mg/kg+flurbiprofen 2 mg/kg+Tropisetron 5 mg+0.9%NaCl=100 mL. Write the Visual analogue score(VAS)during both silence and 90° turn over situation,Ramsay score at 2,4,8,12,24,48 h after the operation and pressing times of PCIA and the side effect. Result:Compared with group D,patients in group DF showed no significant difference in the Ramsay score and VAS during silence,but a significant decrease in VAS under 90° turn-over was observed,and the difference between the two groups were all statistically significant(P<0.05). The PCIA between the two groups were all no statistically significant. Less side effect were observed in group DF than in group DF. Conclusion:Administration of dezocine combined with flurbiprofen has a preferable therapeutic effect for post-operative movement pain and less side effect as compare to dezocine alone.
