中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
4期
1-2,3
,共3页
抵抗素%心力衰竭%预后
牴抗素%心力衰竭%預後
저항소%심력쇠갈%예후
Resistin%Heart failure%Prognosis
目的：探讨血清抵抗素对心力衰竭预后评估的价值。方法：选取2011年2月-2013年2月在本院收治的85例慢性收缩性心力衰竭患者，入院时采血测定患者血清抵抗素水平、N末端B型钠尿肽（NT-proBNP）及生化指标，心脏彩色超声测定左室射血分数（LVEF）和左心室舒张末内径（LVEDD）等。随访1~2年，记录患者发生心源性死亡、慢性心力衰竭恶化需再住院等主要心血管事件。结果：Pearson相关分析结果显示慢性心力衰竭患者血清抵抗素水平与NT-proBNP水平呈正相关（r=0.562，P<0.05）；与EF呈负相关（r=-0.454， P<0.05）。对比未发生心血管事件的患者，发生心血管事件的患者NT-proBNP为（3583±2872）pg/mL，明显高于未发生心血管事件患者的（1894±1234）pg/mL，抵抗素为（19.2±2.3）ng/mL，明显高于未发生心血管事件患者的（13.5±3.1）ng/mL，差异均有统计学意义（P<0.05）。ROC曲线分析结果显示血清抵抗素水平曲线下面积为0.79，P=0.0001，说明抵抗素预测心力衰竭患者心血管事件有显著意义。结论：血清抵抗素水平检测对心力衰竭患者心血管事件的发生存在预测价值。
目的：探討血清牴抗素對心力衰竭預後評估的價值。方法：選取2011年2月-2013年2月在本院收治的85例慢性收縮性心力衰竭患者，入院時採血測定患者血清牴抗素水平、N末耑B型鈉尿肽（NT-proBNP）及生化指標，心髒綵色超聲測定左室射血分數（LVEF）和左心室舒張末內徑（LVEDD）等。隨訪1~2年，記錄患者髮生心源性死亡、慢性心力衰竭噁化需再住院等主要心血管事件。結果：Pearson相關分析結果顯示慢性心力衰竭患者血清牴抗素水平與NT-proBNP水平呈正相關（r=0.562，P<0.05）；與EF呈負相關（r=-0.454， P<0.05）。對比未髮生心血管事件的患者，髮生心血管事件的患者NT-proBNP為（3583±2872）pg/mL，明顯高于未髮生心血管事件患者的（1894±1234）pg/mL，牴抗素為（19.2±2.3）ng/mL，明顯高于未髮生心血管事件患者的（13.5±3.1）ng/mL，差異均有統計學意義（P<0.05）。ROC麯線分析結果顯示血清牴抗素水平麯線下麵積為0.79，P=0.0001，說明牴抗素預測心力衰竭患者心血管事件有顯著意義。結論：血清牴抗素水平檢測對心力衰竭患者心血管事件的髮生存在預測價值。
목적：탐토혈청저항소대심력쇠갈예후평고적개치。방법：선취2011년2월-2013년2월재본원수치적85례만성수축성심력쇠갈환자，입원시채혈측정환자혈청저항소수평、N말단B형납뇨태（NT-proBNP）급생화지표，심장채색초성측정좌실사혈분수（LVEF）화좌심실서장말내경（LVEDD）등。수방1~2년，기록환자발생심원성사망、만성심력쇠갈악화수재주원등주요심혈관사건。결과：Pearson상관분석결과현시만성심력쇠갈환자혈청저항소수평여NT-proBNP수평정정상관（r=0.562，P<0.05）；여EF정부상관（r=-0.454， P<0.05）。대비미발생심혈관사건적환자，발생심혈관사건적환자NT-proBNP위（3583±2872）pg/mL，명현고우미발생심혈관사건환자적（1894±1234）pg/mL，저항소위（19.2±2.3）ng/mL，명현고우미발생심혈관사건환자적（13.5±3.1）ng/mL，차이균유통계학의의（P<0.05）。ROC곡선분석결과현시혈청저항소수평곡선하면적위0.79，P=0.0001，설명저항소예측심력쇠갈환자심혈관사건유현저의의。결론：혈청저항소수평검측대심력쇠갈환자심혈관사건적발생존재예측개치。
Objective:To explore the prognosis significance of serum resistin in patients with systolic heart failure.Method:85 patients with systolic heart failure were selected in our hospital from February 2011 to February 2013.On admission,the serum resistin,N-terminal pro-brain natriuretic peptide(NT-proBNP)and biochemistry index were analyzed.The patients were followed up 1 to 2 years,and the cardiac death,readmission because of exacerbation of heart failure and other major cardiovascular events were recorded.Result:The serum resistin was positively correlated with NT-proBNP(r=0.562,P<0.05)and negatively correlated with eject fraction in patients with heart failure(r=-0.454,P<0.05).The incidence of cardiovascular events in patients with NT-proBNP was(3583±2872)pg/mL,it was significantly higher than the(1894±1234)pg/mL of without cardiovascular events patients,the serum resistin was(19.2±2.3)ng/mL,it was significantly higher than the(13.5±3.1)ng/mL of without cardiovascular events patients,the differences were statistically significant(P<0.05).ROC curve analysis showed that the area above was 0.79, P=0.0001,suggesting resistin levels may predict cardiovascular events in patients with systolic heart failure.Conclusion:Serum resistin levels may be a new prognostic biomarker for cardiovascular events in patients with systolic heart failure.
