中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
4期
136-137,138
,共3页
孙少霖%朱金山%申玉红%李建生%刘军利
孫少霖%硃金山%申玉紅%李建生%劉軍利
손소림%주금산%신옥홍%리건생%류군리
人乳头瘤病毒%感染%宫颈癌%宫颈上皮内瘤变
人乳頭瘤病毒%感染%宮頸癌%宮頸上皮內瘤變
인유두류병독%감염%궁경암%궁경상피내류변
Human papillomavirus%Infection%Cervical cancer%Cervical intraepithelial neoplasia
目的：对10733例女性宫颈脱落细胞进行人乳头瘤病毒（HPV）基因分型检测，了解HPV基因各亚型感染现状，为宫颈癌的筛查及早期预防治疗提供理论依据。方法：采取核酸分子快速导流杂交分型技术，对10733例女性的宫颈脱落细胞进行核酸的提取和HPV基因分型检测。结果：在10733例女性宫颈脱落细胞中21种HPV基因亚型均被检出，HPV阳性2509例（23.38%，2509/10733），单一亚型感染1780例，感染率为16.58%，多重亚型感染729例，感染率为6.79%；单纯高危型HPV感染1680例，感染率为15.65%，单纯低危型HPV感染503例，感染率为4.69%，高、低危型HPV合并感染326例，感染率为3.04%。HPV检出频次2849次。检出频次较高的5种亚型是（按照由高到低的顺序）HPV-16型（22.50%，641/2849），HPV-6型（13.27%，378/2849），HPV-52型（10.46%，298/2849），HPV-11型（10.35%，295/2849），HPV-58型（7.06%，201/2849）。≤30岁人群HPV感染率较高，与其他年龄组比较差异均有统计学意义（P<0.05）。结论：HPV-16型、HPV-6型、HPV-52型、HPV-11型、HPV-58型为开封地区HPV感染常见亚型，应重视≤30岁人群HPV的筛查。
目的：對10733例女性宮頸脫落細胞進行人乳頭瘤病毒（HPV）基因分型檢測，瞭解HPV基因各亞型感染現狀，為宮頸癌的篩查及早期預防治療提供理論依據。方法：採取覈痠分子快速導流雜交分型技術，對10733例女性的宮頸脫落細胞進行覈痠的提取和HPV基因分型檢測。結果：在10733例女性宮頸脫落細胞中21種HPV基因亞型均被檢齣，HPV暘性2509例（23.38%，2509/10733），單一亞型感染1780例，感染率為16.58%，多重亞型感染729例，感染率為6.79%；單純高危型HPV感染1680例，感染率為15.65%，單純低危型HPV感染503例，感染率為4.69%，高、低危型HPV閤併感染326例，感染率為3.04%。HPV檢齣頻次2849次。檢齣頻次較高的5種亞型是（按照由高到低的順序）HPV-16型（22.50%，641/2849），HPV-6型（13.27%，378/2849），HPV-52型（10.46%，298/2849），HPV-11型（10.35%，295/2849），HPV-58型（7.06%，201/2849）。≤30歲人群HPV感染率較高，與其他年齡組比較差異均有統計學意義（P<0.05）。結論：HPV-16型、HPV-6型、HPV-52型、HPV-11型、HPV-58型為開封地區HPV感染常見亞型，應重視≤30歲人群HPV的篩查。
목적：대10733례녀성궁경탈락세포진행인유두류병독（HPV）기인분형검측，료해HPV기인각아형감염현상，위궁경암적사사급조기예방치료제공이론의거。방법：채취핵산분자쾌속도류잡교분형기술，대10733례녀성적궁경탈락세포진행핵산적제취화HPV기인분형검측。결과：재10733례녀성궁경탈락세포중21충HPV기인아형균피검출，HPV양성2509례（23.38%，2509/10733），단일아형감염1780례，감염솔위16.58%，다중아형감염729례，감염솔위6.79%；단순고위형HPV감염1680례，감염솔위15.65%，단순저위형HPV감염503례，감염솔위4.69%，고、저위형HPV합병감염326례，감염솔위3.04%。HPV검출빈차2849차。검출빈차교고적5충아형시（안조유고도저적순서）HPV-16형（22.50%，641/2849），HPV-6형（13.27%，378/2849），HPV-52형（10.46%，298/2849），HPV-11형（10.35%，295/2849），HPV-58형（7.06%，201/2849）。≤30세인군HPV감염솔교고，여기타년령조비교차이균유통계학의의（P<0.05）。결론：HPV-16형、HPV-6형、HPV-52형、HPV-11형、HPV-58형위개봉지구HPV감염상견아형，응중시≤30세인군HPV적사사。
Objective:To detect the human papilloma virus(HPV)genotyping of 10 733 cases of cervical exfoliated cells for surveying infection of each HPV gene subtype.Method:Quick diversion nucleic acid molecular hybridization classification technology was taken to extract the nucleic acid of 10733 cases of cervical exfoliated cells and the HPV genotyping were detected.Result:In 10733 cases of cervical exfoliated cells,21 types of HPV gene subtypes were detected.HPV was positive in 2509 cases(23.38%,2509/10 733),1780 cases were infected with single HPV subtype,with the infection rate 16.58%.729 cases were infected with Multiple HPV subtype,with the infection rate 6.79%.On the other hand,1680 cases were infected with simple high-risk HPV,with the infection rate 15.65%.503 cases were infected with simple low-risk HPV,with the infection rate 4.69%,326 cases were infected with high-risk and low-risk HPV,with the infection rate 3.04%.HPV detection frequency were 2849 times.5 types of HPV subtypes detected most frequently were(from high to low)HPV-16(22.50%,641/2849),HPV-6(13.27%,378/2849),HPV-52(10.46%,298/2849),HPV-11(10.35%, 295/2849)and HPV-58(7.06%,201/2849)respectively.The infection rate of women less than 30 years old were higher than those of other women,the differences were statistically significant(P<0.05).Conclusion:HPV-16,HPV-6,HPV-52,HPV-11 and HPV-58 are common HPV subtypes in Kaifeng.Screening for HPV infecting of women less than 30 years old should be paid attention.
