CAJ | 학술논문

目的：探讨辛伐他汀对2型糖尿病肾病患者P-选择素和C-肽的影响。方法将54例2型糖尿病肾病患者随机分为治疗组和对照组。分别测定各组治疗前后血脂变化、P选择素及C-肽含量以及尿白蛋白排泄率。结果两组间血脂水平、P选择素及C-肽含量以及尿白蛋白排泄率水平差异有统计学意义（P＜0.05，P＜0.01，P＜0.01，P＜0.01)。结论辛伐他汀除了降脂途径外，还可通过降低P-选择素表达水平、升高C-肽表达水平发挥肾脏保护作用，可能成为其治疗糖尿病肾病新的靶点。
목적：탐토신벌타정대2형당뇨병신병환자P-선택소화C-태적영향。방법장54례2형당뇨병신병환자수궤분위치료조화대조조。분별측정각조치료전후혈지변화、P선택소급C-태함량이급뇨백단백배설솔。결과량조간혈지수평、P선택소급C-태함량이급뇨백단백배설솔수평차이유통계학의의（P＜0.05，P＜0.01，P＜0.01，P＜0.01)。결론신벌타정제료강지도경외，환가통과강저P-선택소표체수평、승고C-태표체수평발휘신장보호작용，가능성위기치료당뇨병신병신적파점。
Objective: To investigate the af ect of Simvastatin on P-selectin and C-peptide in patients with type 2 diabetic nephropathy. Methods: 54 cases of type 2 diabetic nephropathy patients were divided into treatment group and control group randomly. Each group were measured of lipid changes,P-selectin and C-peptide levels and urinary albumin excretion rate before and after treatment. Results:The dif erence of serum lipid levels,P-selectin and C-peptide levels and urinary albumin excretion rate between the two groups was statistical y significant ( P<0.05,P<0.01,P<0.01,P<0.01). Conclusions: In addition to lipid-lowering ways,simvastatin but also reducing the levels of P-selectin expression,elevated levels of C-peptide expression to play a protective role with kidney,and it may become a new target for treatment of diabetic nephropathy.