中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
5期
154-156
,共3页
去乙酰酶抑制剂%骨性关节炎%组蛋白乙酰化%HDAC分子
去乙酰酶抑製劑%骨性關節炎%組蛋白乙酰化%HDAC分子
거을선매억제제%골성관절염%조단백을선화%HDAC분자
Deacetylase inhibitors%Osteoarthritis%Histone acetylation%HDAC molecules
目的：对近年来在骨性关节炎方面的相关应用研究及新进展做了综合概述。方法：通过对动物的体内外造模、诱导或抑制的方法，探寻软骨降解的过程，并模拟机械应力对人软骨细胞作用，观察压力对软骨降解的影响。结果：去乙酰酶抑制剂不仅可以作用于组蛋白，对非组蛋白如转录因子也有影响，可以延缓软骨细胞凋亡，还可调节疼痛反应。结论：从体外实验的分子和细胞以及体外动物实验可以看出，去乙酰酶抑制剂的确对于OA有一定治疗作用，是潜在的OA临床治疗药物。
目的：對近年來在骨性關節炎方麵的相關應用研究及新進展做瞭綜閤概述。方法：通過對動物的體內外造模、誘導或抑製的方法，探尋軟骨降解的過程，併模擬機械應力對人軟骨細胞作用，觀察壓力對軟骨降解的影響。結果：去乙酰酶抑製劑不僅可以作用于組蛋白，對非組蛋白如轉錄因子也有影響，可以延緩軟骨細胞凋亡，還可調節疼痛反應。結論：從體外實驗的分子和細胞以及體外動物實驗可以看齣，去乙酰酶抑製劑的確對于OA有一定治療作用，是潛在的OA臨床治療藥物。
목적：대근년래재골성관절염방면적상관응용연구급신진전주료종합개술。방법：통과대동물적체내외조모、유도혹억제적방법，탐심연골강해적과정，병모의궤계응력대인연골세포작용，관찰압력대연골강해적영향。결과：거을선매억제제불부가이작용우조단백，대비조단백여전록인자야유영향，가이연완연골세포조망，환가조절동통반응。결론：종체외실험적분자화세포이급체외동물실험가이간출，거을선매억제제적학대우OA유일정치료작용，시잠재적OA림상치료약물。
Objective:Deacetylase inhibitors is a new class of drugs in recent years,can inhibit the in vivo histone deacetylase function,and used in the treatment of cancer and neurodegenerative diseases. Because of its side effect of better therapeutic effect and less,histone deacetylase inhibitors began more and more application in the treatment of other diseases,the paper makes a comprehensive survey of the relevant research and application in OA and its new developmentin recent years. Method:The animal model in vivo and in vitro,induction or inhibition,explored the process of cartilage degradation,and simulated the mechanical stress on human chondrocytes,observed the effects of pressure on cartilagedegradation. Result:The deacetylase inhibitors could not only acts on histone,also had an impact on the non histone proteins such as transcription factors,could delay the apoptosis of cartilage cells,regulated the pain reaction of molecular. Conclusion:In vitro and cells as well as in vitro animal experiment,can be seen that the deacetylase inhibitor indeed for OA has a certain therapeutic effect,is the clinical treatment of OA potential drug.
