中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
5期
71-72,73
,共3页
丙种球蛋白%布地奈德%异丙托溴铵%重症毛细支气管炎
丙種毬蛋白%佈地奈德%異丙託溴銨%重癥毛細支氣管炎
병충구단백%포지내덕%이병탁추안%중증모세지기관염
Gamma globulin%Budesonide%Ipratropium bromide%Severe bronchiolitis
目的：探讨静脉用大剂量丙种球蛋白联合应用布地奈德、异丙托溴铵雾化吸入用于重症毛细支气管炎患者的治疗效果。方法：选取重症毛细支气管炎患儿120例并将其随机分为观察组和对照组，对照组采用常规治疗，即予糖皮质激素治疗、抗病毒、吸氧等常规对症治疗方法；观察组在对症治疗的基础上采用大剂量静脉用丙种球蛋白静滴，同时联合应用布地奈德、异丙托溴铵雾化吸入的治疗方法。经治疗5d后，观察和比较两组患者喘息、哮鸣音减轻或消失情况及治疗后症状体征消失时间。结果：治疗5d后，观察组显效率和有效率分别为56.5％和95.0％；明显高于对照组的41.7％和78.3％（P<0.01）。观察组呼吸困难、咳嗽、喘息、哮鸣音、痰鸣音等消失时间与对照组比较差异有统计学意义（P<0.01）。结论：大剂量丙种球蛋白静脉滴注联合布地奈德、异丙托溴铵雾化吸入治疗重症毛细支气管炎能从多角度、多渠道抑制免疫反应，减少趋化因子和细胞介质的释放，舒张支气管平滑肌，改善肺功能，提高机体非特异性免疫力，疗效确切，是一种安全有效的治疗方法。
目的：探討靜脈用大劑量丙種毬蛋白聯閤應用佈地奈德、異丙託溴銨霧化吸入用于重癥毛細支氣管炎患者的治療效果。方法：選取重癥毛細支氣管炎患兒120例併將其隨機分為觀察組和對照組，對照組採用常規治療，即予糖皮質激素治療、抗病毒、吸氧等常規對癥治療方法；觀察組在對癥治療的基礎上採用大劑量靜脈用丙種毬蛋白靜滴，同時聯閤應用佈地奈德、異丙託溴銨霧化吸入的治療方法。經治療5d後，觀察和比較兩組患者喘息、哮鳴音減輕或消失情況及治療後癥狀體徵消失時間。結果：治療5d後，觀察組顯效率和有效率分彆為56.5％和95.0％；明顯高于對照組的41.7％和78.3％（P<0.01）。觀察組呼吸睏難、咳嗽、喘息、哮鳴音、痰鳴音等消失時間與對照組比較差異有統計學意義（P<0.01）。結論：大劑量丙種毬蛋白靜脈滴註聯閤佈地奈德、異丙託溴銨霧化吸入治療重癥毛細支氣管炎能從多角度、多渠道抑製免疫反應，減少趨化因子和細胞介質的釋放，舒張支氣管平滑肌，改善肺功能，提高機體非特異性免疫力，療效確切，是一種安全有效的治療方法。
목적：탐토정맥용대제량병충구단백연합응용포지내덕、이병탁추안무화흡입용우중증모세지기관염환자적치료효과。방법：선취중증모세지기관염환인120례병장기수궤분위관찰조화대조조，대조조채용상규치료，즉여당피질격소치료、항병독、흡양등상규대증치료방법；관찰조재대증치료적기출상채용대제량정맥용병충구단백정적，동시연합응용포지내덕、이병탁추안무화흡입적치료방법。경치료5d후，관찰화비교량조환자천식、효명음감경혹소실정황급치료후증상체정소실시간。결과：치료5d후，관찰조현효솔화유효솔분별위56.5％화95.0％；명현고우대조조적41.7％화78.3％（P<0.01）。관찰조호흡곤난、해수、천식、효명음、담명음등소실시간여대조조비교차이유통계학의의（P<0.01）。결론：대제량병충구단백정맥적주연합포지내덕、이병탁추안무화흡입치료중증모세지기관염능종다각도、다거도억제면역반응，감소추화인자화세포개질적석방，서장지기관평활기，개선폐공능，제고궤체비특이성면역력，료효학절，시일충안전유효적치료방법。
Objective:To study effect of intravenous high dose of gamma globulin combined with budesonide,ipratropium bromide inhalation in treatment of severe bronchiolitis. Method:120 cases of severe bronchiolitis were randomly divided into observation group and control group,the control group was treated with the conventional treatment,namely to glucocorticoid treatment,antiviral,oxygen conventional symptomatic treatment. The observation group was treated with the high dose intravenous immunoglobulin for intravenous drip,combined application budesonide,ipratropium bromide aerosol inhalation treatment on the basis of symptomatic treatment. After treatment of 5 d,the time of asthma,wheeze relieved or disappeared and the symptoms disappeared of two groups were observed and compared. Result:After treatment of 5 d,significant efficiency and effectiveness in observation group were 56.5%and 95.0%respectively,and were higher than 41.7%and 78.3%in the control group(P<0.01). The time of dyspnea, cough,wheezing,wheezing,sputum toot sound disappear showed a significant difference between the two groups(P<0.01). Conclusion:High dose of intravenous gamma globulin combined with budesonide,ipratropium bromide aerosol inhalation in the treatment of severe bronchiolitis can inhibit the immune response from the multi angle,multi channels,reduce chemokine and cytokine release,relax bronchial smooth muscle,improve lung function, improve the non-specific immunity,it is a kind of safe and effective treatment method.
