中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
5期
8-9
,共2页
董赟%吴毓东%李德俊%付琴%程晓丹
董赟%吳毓東%李德俊%付琴%程曉丹
동빈%오육동%리덕준%부금%정효단
乳腺癌%聚乙二醇化重组人粒细胞刺激因子%粒细胞减少
乳腺癌%聚乙二醇化重組人粒細胞刺激因子%粒細胞減少
유선암%취을이순화중조인립세포자격인자%립세포감소
Breast cancer%Polyethylene glycol(peg)filgrastim%Granulocytopenia
目的:比较乳腺癌TAC方案化疗后,应用聚乙二醇化重组人粒细胞刺激因子和人粒细胞刺激因子预防粒细胞减少的临床疗效。方法:选取2013年1-8月入院接受TAC方案化疗的乳腺癌患者共60例。30例为试验组,化疗结束后48 h给予聚乙二醇化重组人粒细胞刺激因子(PEG-rhG-CSF);30例为对照组,化疗结束后48 h给予重组人粒细胞刺激因子(rhG-CSF)。结果:试验组化疗间歇期中性粒细胞减少、感染病例明显少于对照组,差异有统计学意义(P<0.05)。结论:乳腺癌TAC方案化疗后应用聚乙二醇化重组人粒细胞刺激因子预防中性粒细胞减少疗效确切,值得临床推广应用。
目的:比較乳腺癌TAC方案化療後,應用聚乙二醇化重組人粒細胞刺激因子和人粒細胞刺激因子預防粒細胞減少的臨床療效。方法:選取2013年1-8月入院接受TAC方案化療的乳腺癌患者共60例。30例為試驗組,化療結束後48 h給予聚乙二醇化重組人粒細胞刺激因子(PEG-rhG-CSF);30例為對照組,化療結束後48 h給予重組人粒細胞刺激因子(rhG-CSF)。結果:試驗組化療間歇期中性粒細胞減少、感染病例明顯少于對照組,差異有統計學意義(P<0.05)。結論:乳腺癌TAC方案化療後應用聚乙二醇化重組人粒細胞刺激因子預防中性粒細胞減少療效確切,值得臨床推廣應用。
목적:비교유선암TAC방안화료후,응용취을이순화중조인립세포자격인자화인립세포자격인자예방립세포감소적림상료효。방법:선취2013년1-8월입원접수TAC방안화료적유선암환자공60례。30례위시험조,화료결속후48 h급여취을이순화중조인립세포자격인자(PEG-rhG-CSF);30례위대조조,화료결속후48 h급여중조인립세포자격인자(rhG-CSF)。결과:시험조화료간헐기중성립세포감소、감염병례명현소우대조조,차이유통계학의의(P<0.05)。결론:유선암TAC방안화료후응용취을이순화중조인립세포자격인자예방중성립세포감소료효학절,치득림상추엄응용。
Objective:To compare the effect of the application of polyethylene glycol(peg)recombinant human granulocyte stimulating factor and recombinant human granulocyte stimulating factor to prevent granulocytopenia after TAC scheme chemotherapy. Method:60 cases of breast cancer treated by TAC scheme chemotherapy from January 2013 to August 2013 hospitalized were randomly divided into two groups. The experimental group was treated with the polyethylene glycol recombinant human granulocyte stimulating factor(PEG-rhG CSF)after the end of the chemotherapy for 48 hours.The control group was treated with recombinant human granulocyte stimulating factor(rhG CSF)after the end of the chemotherapy for 48 hours.Result:The case of neutropenia and infection of experimental group in chemotherapy intermission were obviously less than that of the control group,there was statistical significance(P<0.05).Conclusion:The curative effect of polyethylene glycol(peg)of recombinant human granulocyte stimulating factor injection in preventing breast cancer TAC scheme post-chemotherapy neutropenia is good,and is worth to be widely applied in clinical.