CAJ | 학술논문

目的评价紫杉醇与顺铂不同给药方式治疗晚期卵巢癌的临床疗效.方法选取2011年6月至2013年5月我院收治的100例晚期卵巢癌患者,随机分为两组,其中观察组50例,采用紫杉醇静脉滴注联合顺铂腹腔内给药治疗,对照组50例,采用紫杉醇联合顺铂静脉滴注给药,观察并比较两组患者的临床疗效及不良反应的发生率.结果观察组有效率为84％,对照组有效率为56％,两组患者近期疗效相比较差异有统计学意义(P＜0.05);在不良反应的发生上,白细胞减少程度相比较差异无统计学意义(P＞0.05),但是观察组恶心呕吐、脱发、肾功能损害、肌肉关节痛的发生率明显低于对照组,差异有统计学意义(P＜0.05).结论紫杉醇静脉注射联合顺铂腹腔内给药治疗晚期卵巢癌疗效好,不良反应发生率低,值得在临床上予以推广.
목적 평개자삼순여순박불동급약방식치료만기란소암적림상료효.방법 선취2011년6월지2013년5월아원수치적100례만기란소암환자,수궤분위량조,기중관찰조50례,채용자삼순정맥적주연합순박복강내급약치료,대조조50례,채용자삼순연합순박정맥적주급약,관찰병비교량조환자적림상료효급불량반응적발생솔.결과 관찰조유효솔위84％,대조조유효솔위56％,량조환자근기료효상비교차이유통계학의의(P＜0.05);재불량반응적발생상,백세포감소정도상비교차이무통계학의의(P＞0.05),단시관찰조악심구토、탈발、신공능손해、기육관절통적발생솔명현저우대조조,차이유통계학의의(P＜0.05).결론 자삼순정맥주사연합순박복강내급약치료만기란소암료효호,불량반응발생솔저,치득재림상상여이추엄.
Objective To evaluate the different modes of administration of paclitaxel and cisplatin in patients with advanced ovarian cancer.Methods From June 2011 to May 2013,100 cases of advanced ovarian cancer in our hospital were randomly divided into observation group and control group,50 cases in each group.Observation group used the intravenous infusion of paclitaxel plus cisplatin intraperitoneal treatment,while control group used paclitaxel and cisplatin administered intravenously.The clinical efficacy and the incidence of adverse reactions were observed and compared between two groups.Results The effective rate in observation group was 84％,while that in control group was 56％,with statistically significant difference in short-term efficacy between two groups (P ＜ 0.05).The incidence of leukopenia had no statistically significant difference between two groups (P ＜ 0.05).The incidences of nausea and vomiting,hair loss,kidney damage,muscle and joint pain in observation group were significantly lower than those in control group,with statistically significant differences (P ＜ 0.05).Conclusion Intravenous administration of paclitaxel plus cisplatin intraperitoneal treatment of advanced ovarian cancer has good efficacy,with fewer adverse reactions,which should be promoted in clinical practice.