CAJ | 학술논문

目的观察健脾祛湿颗粒口服配合消炎止痒洗剂湿敷治疗湿疹的临床疗效.方法将90例湿疹患者随机分为治疗组和对照组,各45例,治疗组采用本科自制的健脾祛湿颗粒,每天一剂,分早晚两次温水冲服,配合消炎止痒洗剂:将20 g药粉加2000 ml温开水浸泡20 min,待冷却至室温后,将5～6层纱布浸渍于药液中片刻后取出,拧至不滴水后湿敷患处,每次20 min,每天2～3次.对照组采用莫匹罗星软膏联合糠酸莫米松乳膏外用治疗.两组均治疗30天,观察两组治疗前后瘙痒程度、皮疹形态、皮疹面积积分及总积分,并比较两组临床疗效和治疗期间出现的不良反应.结果治疗后,治疗组的皮疹形态、皮疹面积积分均低于对照组,经比较差异有统计学意义(P＜ 0.05,P＜ 0.01),对照组瘙痒程度积分高于治疗组,经比较差异有统计学意义(P＜0.05),而两组的总积分比较差异无统计学意义(P＞ 0.05);治疗组总有效率为86.7％,对照组为77.7％,经Riddt分析,差异无统计学意义(u=-1.590,P＞ 0.05);治疗组中总共有3例出现皮肤灼痛感及色素沉着不良反应,而对照组出现8例.结论健脾祛湿颗粒口服配合消炎止痒洗剂湿敷治疗湿疹与莫匹罗星软膏联合糠酸莫米松乳膏外用治疗相比,总体疗效相当,但前者在改善患者皮疹形态和皮疹面积方面优于后者,且不良反应相对较少,不失为临床上治疗湿疹的一种可选方案.
목적 관찰건비거습과립구복배합소염지양세제습부치료습진적림상료효.방법 장90례습진환자수궤분위치료조화대조조,각45례,치료조채용본과자제적건비거습과립,매천일제,분조만량차온수충복,배합소염지양세제:장20 g약분가2000 ml온개수침포20 min,대냉각지실온후,장5～6층사포침지우약액중편각후취출,녕지불적수후습부환처,매차20 min,매천2～3차.대조조채용막필라성연고연합강산막미송유고외용치료.량조균치료30천,관찰량조치료전후소양정도、피진형태、피진면적적분급총적분,병비교량조림상료효화치료기간출현적불량반응.결과 치료후,치료조적피진형태、피진면적적분균저우대조조,경비교차이유통계학의의(P＜ 0.05,P＜ 0.01),대조조소양정도적분고우치료조,경비교차이유통계학의의(P＜0.05),이량조적총적분비교차이무통계학의의(P＞ 0.05);치료조총유효솔위86.7％,대조조위77.7％,경Riddt분석,차이무통계학의의(u=-1.590,P＞ 0.05);치료조중총공유3례출현피부작통감급색소침착불량반응,이대조조출현8례.결론 건비거습과립구복배합소염지양세제습부치료습진여막필라성연고연합강산막미송유고외용치료상비,총체료효상당,단전자재개선환자피진형태화피진면적방면우우후자,차불량반응상대교소,불실위림상상치료습진적일충가선방안.
Objective To observe the curative effect of oral particles medicine of spleenstrengthening and damp-removing concomitant with antiphlogistic and antipruritic lotion wet dressing in the treatment of eczema.Methods 90 cases of eczema were randomly divided into treatment group and control group,45 cases in each group.Treatment group was given the treatment of self-made spleen-strengthening and damp-removing particles medicine,one dose a day,infused with warm water twice a day in the morning and night,and combined with antiphlogistic and antipruritic lotion:20 g powder soaked with 2000 ml warm water for 20 min,after cooling to room temperature,5-6 layers of gauze dipped in the liquid for a moment,when the gauze didn' t drip wetted the affected area about 20 minutes,2-3 times a day.Control group was given the treatment of topical mupirocin ointment combined mometasone furoate cream.The treatment lasted for 30 days.Observed scores of pruritus,rash form,rash area and total score in two groups before and after the treatment,at the same time compared the clinical efficacy and adverse reactions occurred during the treatment.Results After treatment,scores of rash form and rash area in treatment group were lower than those in control group,with statistically significant differences (P ＜ 0.05 or P ＜ 0.01); pruritus score in treatment group was higher than that in control group,with statistically significant difference (P ＜ 0.05); there was no statisticallysignificant difference in total score between two groups (P ＞ 0.05).The total effective rate in treatment group was 86.7％,while that in control group was 77.7％,without statistically significant difference (u =-1.590,P ＞ 0.05).There were 3 cases of skin burning sensation and pigmentation in treatment group,8 cases in control group.Conclusions Oral particles medicine of spleen-strengthening and damp-removing concomitant with antiphlogistic and antipruritic lotion wet dressing in the treatment of eczema had the same overall effect as the treatment of topical mupirocin ointment combined with mometasone furoate cream,but the former was better in improving patients' rash form and area with fewer adverse reactions,which could be an alternative in the clinical treatment of eczema.