CAJ | 학술논문

目的：分析降钙素原(PCT)、超敏C反应蛋白(hs-CRP)和白细胞介素-6(IL-6)在小儿急性上呼吸道感染(AU-RI)时血清水平变化及其临床诊断价值。方法：分别收集100例 AURI患儿,分为细菌感染组和病毒感染组(各50例),采用 ELISA和免疫比浊法测定其血清PCT、hs-CRP、IL-6等指标,分析两病例组间及与健康体检儿童组间差异,并绘制细菌感染组上述检测指标的 ROC曲线,比较其临床诊断价值。结果：细菌感染组血清 PCT、hs-CRP 与IL-6水平明显高于病毒感染组及健康对照组,差异有统计学意义(P<0.05)；病毒感染组 PCT、hs-CRP 和 IL-6水平与健康对照组之间差异无统计学意义(P>0.05)。对诊断细菌性 AURI,血清 PCT的 ROC曲线下面积最大；灵敏度、特异度、阳性似然比明显高于 hs-CRP和 IL-6,阴性似然比显著低于 IL-6,差异均有统计学意义(P<0.05)。结论：血清PCT与 hs-CRP、IL-6比较,其对小儿细菌性 AURI具有更高的诊断价值及早期诊断意义。
목적：분석강개소원(PCT)、초민C반응단백(hs-CRP)화백세포개소-6(IL-6)재소인급성상호흡도감염(AU-RI)시혈청수평변화급기림상진단개치。방법：분별수집100례 AURI환인,분위세균감염조화병독감염조(각50례),채용 ELISA화면역비탁법측정기혈청PCT、hs-CRP、IL-6등지표,분석량병례조간급여건강체검인동조간차이,병회제세균감염조상술검측지표적 ROC곡선,비교기림상진단개치。결과：세균감염조혈청 PCT、hs-CRP 여IL-6수평명현고우병독감염조급건강대조조,차이유통계학의의(P<0.05)；병독감염조 PCT、hs-CRP 화 IL-6수평여건강대조조지간차이무통계학의의(P>0.05)。대진단세균성 AURI,혈청 PCT적 ROC곡선하면적최대；령민도、특이도、양성사연비명현고우 hs-CRP화 IL-6,음성사연비현저저우 IL-6,차이균유통계학의의(P<0.05)。결론：혈청PCT여 hs-CRP、IL-6비교,기대소인세균성 AURI구유경고적진단개치급조기진단의의。
Objective:To analyze the clinical diagnostic value of serum procalcitonin (PCT),high-sensitivity c-reactive pro-tein (hs-CRP)and interleukin-6 (IL-6)for children with acute respiratory infections and provide the basis for clinical diagnosis and treatment.Method:100 cases of acute respiratory infections specimens from children were collected, which included the bacterial infection group (50 cases)and viral infection group (50 cases)compared with healthy control group (50 cases).ELISA and immunonephelometry methods were applicated to detect the levels of PCT,hs-CRP and IL-6 and drawed the ROC curves for bacterial infection group to compare the clinical diagnostic value.Re-sults:The levels of PCT,hs-CRP and IL-6 in bacterial infection group were higher than viral infection group and the control group and the difference was statistically significant (P<0.05);while PCT,hs-CRP and IL-6 levels in viral infection group were normal or slightly elevated and there was no significant difference (P> 0.05)compared with the healthy control group.Serum PCT had the highest diagnostic value diagnosis in the children with acute respira-tory infections among indicators.Conclusion:Serum PCT has a higher diagnostic value compared with hs-CRP and IL-6 for acute respiratory infections in children with bacterial pneumonia which is crucial for early diagnosis and treatment in children with acute respiratory infections.