CAJ | 학술논문

目的：建立青年SD大鼠营养性肥胖模型。方法：出生4周的40只SD大鼠将其随机分为对照组与模型组，对照组给予普通饲料，模型组给予改良的高脂饲料，共饲养8周。观察对照组与模型组体重、Lee's指数及总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)的变化情况。结果：在高脂饲养8周后，模型组平均体重、Lee's指数、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白均明显高于对照组(P<0.05)。结论：改良高脂饲料配方、迎合SD大鼠磨牙习性和混合喂养方式可以诱导青年SD大鼠营养性肥胖，致肥率达到83%。
목적：건립청년SD대서영양성비반모형。방법：출생4주적40지SD대서장기수궤분위대조조여모형조，대조조급여보통사료，모형조급여개량적고지사료，공사양8주。관찰대조조여모형조체중、Lee's지수급총담고순(TC)、감유삼지(TG)、저밀도지단백(LDL-C)적변화정황。결과：재고지사양8주후，모형조평균체중、Lee's지수、총담고순(TC)、감유삼지(TG)、저밀도지단백균명현고우대조조(P<0.05)。결론：개량고지사료배방、영합SD대서마아습성화혼합위양방식가이유도청년SD대서영양성비반，치비솔체도83%。
Objective To establish a model of the young nutritional obesity SD rats. Methods 40 4-weeks old SD rats were fed on normal diet for 3 days in sense of adaptability, then randomly separated into two groups. The normal control group was given normal diet, model group was given modified fat diet, in total of 8 weeks. Monitoring the weight, Lee's index and serum lipids, total cholesterol (TC), triglyceride (TG), low density lipopro-tein (LDL-C) changes in control group and model group. Results After 8 weeks, the model group weight, Lees in-dex, total cholesterol (TC), triglyceride (TG), low density lipoprotein were significantly higher (P<0.05, P <0.01) than normal group. Conclusion The modified high-fat diet recipes that cater SD rat molar habits, undertaking mixed feeding methods for a reasonable feeding time can trigger young SD rats nutritional obesity, which caused the fat rate reached 83%.