中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2014年
5期
84-85
,共2页
冠状动脉疾病%辛伐他汀%高血脂症
冠狀動脈疾病%辛伐他汀%高血脂癥
관상동맥질병%신벌타정%고혈지증
Coronary artery disease%Simvastatin%Hyperlipidemia
目的：观察不同剂量辛伐他汀治疗冠心病伴高血脂症的疗效及不良反应。方法将100例冠心病伴高血脂症患者随机分为3组：A组给予辛伐他汀20mg/d口服，B组给予辛伐他汀40mg/d口服，C组给予辛伐他汀80mg/d口服。3组分别在治疗前及治疗过程中定期检测血清胆固醇（TC）、低密度脂蛋白（LDL-C）等及安全性指标（TG、ALT、Cr、BUN及CK），比较不同剂量辛伐他汀的疗效及安全性。结果辛伐他汀80mg/d剂量降低TC、LDL-C的作用显著。结论辛伐他汀常规剂量（80mg）治疗冠心病伴高血脂症可取得较满意疗效。
目的：觀察不同劑量辛伐他汀治療冠心病伴高血脂癥的療效及不良反應。方法將100例冠心病伴高血脂癥患者隨機分為3組：A組給予辛伐他汀20mg/d口服，B組給予辛伐他汀40mg/d口服，C組給予辛伐他汀80mg/d口服。3組分彆在治療前及治療過程中定期檢測血清膽固醇（TC）、低密度脂蛋白（LDL-C）等及安全性指標（TG、ALT、Cr、BUN及CK），比較不同劑量辛伐他汀的療效及安全性。結果辛伐他汀80mg/d劑量降低TC、LDL-C的作用顯著。結論辛伐他汀常規劑量（80mg）治療冠心病伴高血脂癥可取得較滿意療效。
목적：관찰불동제량신벌타정치료관심병반고혈지증적료효급불량반응。방법장100례관심병반고혈지증환자수궤분위3조：A조급여신벌타정20mg/d구복，B조급여신벌타정40mg/d구복，C조급여신벌타정80mg/d구복。3조분별재치료전급치료과정중정기검측혈청담고순（TC）、저밀도지단백（LDL-C）등급안전성지표（TG、ALT、Cr、BUN급CK），비교불동제량신벌타정적료효급안전성。결과신벌타정80mg/d제량강저TC、LDL-C적작용현저。결론신벌타정상규제량（80mg）치료관심병반고혈지증가취득교만의료효。
the efficacy and adverse reaction of different dose of simvastatin in treating coronary heart disease with hyperlipidemia.Methods 100 patients with coronary heart disease complicated withhyperlipemia were randomly divided into 3 groups: A group were given simvastatin 20mg/d oral, B group were given simvastatin 40mg/d oral, C group were given simvastatin 80mg/d oral. In the 3 groups before treatment and periodical y during the detection of serum cholesterol (TC), low density lipoprotein (LDL-C) index and safety (TG, ALT, CR, BUN and CK), to compare the efficacy and safety of different doses of simvastatin. Results simvastatin dose of 80mg/d reduced TC, LDL-C effect. Conclusion simvastatinconventional dose (80mg) in treating coronary heart disease withhyperlipidemia can obtain satisfactory effects.
