CAJ | 학술논문

信号转导子与转录激活子3（STAT3）是一种存在于细胞质内的双功能蛋白，可以被多种酪氨酸激酶激活，激活后发生磷酸化，形成二聚体转入细胞核内，调节细胞生长、分化、凋亡相关基因的表达，是多条致癌通路的汇集点，在大多数肿瘤细胞内呈持续性激活，在肿瘤的发生、发展、转移中起了重要作用。近几年的研究表明，STAT3能在很多环节参与调节肿瘤的免疫逃逸，可能是肿瘤免疫治疗的一个重要靶点。
신호전도자여전록격활자3（STAT3）시일충존재우세포질내적쌍공능단백，가이피다충락안산격매격활，격활후발생린산화，형성이취체전입세포핵내，조절세포생장、분화、조망상관기인적표체，시다조치암통로적회집점，재대다수종류세포내정지속성격활，재종류적발생、발전、전이중기료중요작용。근궤년적연구표명，STAT3능재흔다배절삼여조절종류적면역도일，가능시종류면역치료적일개중요파점。
Signal transducer and activator of transcription 3 is a dual function of protein in the cytoplasm, which is constitutively activated at a very high frequency in human cancer, on phosphorylation of STAT3 monomers by tyrosine kinases, the monomers dimerized, translocate to the nucleus, and bind to specific promoter sequences, thereby inducing expression of multiple genes associated with cellular proliferation and survival, which is a point of convergence for many oncogenic pathways, play a crucial role in tumor initiation and progression. In recent study, STAT3 has emerged as a critical mediator of tumor immune evasion at multiple levels, provide a target for cancer immunotherapy.