CAJ | 학술논문

目的： Meta分析TNF-α-308A/G单核苷酸多态性与皮肌炎相关性。方法在PubMed、EBSCO、EMBASE、中国学术期刊全文数据库（CNKI）、中国生物医学文献数据库（CBM）、万方数据库中查询肿瘤坏死因子α-308（TNF-α-308）位点多态性与皮肌炎相关性的文献。用Meta分析的方法分析基因型AA vs. GG，GA vs. GG，AA vs. GG＋GA，GA＋AA vs. GG和A vs. G在皮肌炎组与对照组中是否有差异。结果共纳入5篇文献进入本研究（462例皮肌炎患者，763例健康对照）。对总体人群进行Meta分析，发现TNF-α-308A等位基因与皮肌炎相关（OR＝2.48，95%CI＝2.00～3.07，P＜0.001）；将人群按照种族分层，发现-308A与高加索人群皮肌炎相关（OR＝2.50，95%CI＝1.99～3.14，P＜0.001）。基因型AA vs. GG，GA vs. GG，AA vs. GG＋GA，GA＋AA vs. GG在皮肌炎组与对照组中均有统计学差异。结论 TNF-α-308A等位基因或基因型与高加索人群皮肌炎相关，TNF-α-308A等位基因或基因型可能是高加索人群皮肌炎的易感因素。
목적： Meta분석TNF-α-308A/G단핵감산다태성여피기염상관성。방법재PubMed、EBSCO、EMBASE、중국학술기간전문수거고（CNKI）、중국생물의학문헌수거고（CBM）、만방수거고중사순종류배사인자α-308（TNF-α-308）위점다태성여피기염상관성적문헌。용Meta분석적방법분석기인형AA vs. GG，GA vs. GG，AA vs. GG＋GA，GA＋AA vs. GG화A vs. G재피기염조여대조조중시부유차이。결과공납입5편문헌진입본연구（462례피기염환자，763례건강대조）。대총체인군진행Meta분석，발현TNF-α-308A등위기인여피기염상관（OR＝2.48，95%CI＝2.00～3.07，P＜0.001）；장인군안조충족분층，발현-308A여고가색인군피기염상관（OR＝2.50，95%CI＝1.99～3.14，P＜0.001）。기인형AA vs. GG，GA vs. GG，AA vs. GG＋GA，GA＋AA vs. GG재피기염조여대조조중균유통계학차이。결론 TNF-α-308A등위기인혹기인형여고가색인군피기염상관，TNF-α-308A등위기인혹기인형가능시고가색인군피기염적역감인소。
Objective We detected the association of TNF-α-308A/G single nucleotide polymorphism (SNP) and dermatomyositis through Meta analysis method. Methods We searched all the publications about the association between TNF-α promoter -308A/G polymorphism and DM from PubMed, EBSCO, EMBASE, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), and Wanfang (Chinese). Meta-analysis was performed for genotypes AA versus GG, GA versus GG, AA versus GG+GA, GA+AA versus GG, and A allele versus G allele in a fixed/random effect model. Results A total of 5 studies (462 cases and 763 controls) were included in the current Meta-analysis. When all groups were pooled, significant association of A allele and increased DM risk was found (OR=2.48, 95% CI=2.00-3.07, P<0.001). When analyses were restricted to more race homogeneous populations, significant association of A allele with increased DM risk was found in Caucasian population (OR=2.50, 95%CI=1.99-3.14, P<0.001). Significant association between TNF-αpromoter -308 polymorphism and DM was observed when examining the contrast of AA+GA versus GG, AA versus GA+GG, AA versus GG, and GA versus GG. Conclusion This Meta-analysis demonstrated significant association between TNF-α-308A/G polymorphism and DM in Caucasian populations, implying that TNF-α-308A allele was a risk factor in Caucasian DM patients.