CAJ | 학술논문

目的：探讨自体骨髓基质干细胞移植治疗出血性脑卒中后遗症的临床疗效。方法对2011年1月-2012年6月20例出血性脑卒中患者采用立体定向技术进行自体骨髓基质干细胞移植术，于术前、术后1月、6月应用功能独立性测量(FIM)和神经功能缺损评分进行功能性评分。结果患者术后6个月内临床症状好转有效率达85%，无严重并发症出现。手术治疗1个月和6个月后FIM评分、神经功能缺损评分与治疗前相比明显升高，差异有统计学意义(P<0.05)，且随随访时间增加评分改善更明显。结论自体骨髓基质干细胞移植治疗可改善出血性脑卒中患者后遗症，对于提高患者运动功能和生活质量有一定帮助，但其长期疗效仍需大样本多中心的临床研究进一步观察。
목적：탐토자체골수기질간세포이식치료출혈성뇌졸중후유증적림상료효。방법대2011년1월-2012년6월20례출혈성뇌졸중환자채용입체정향기술진행자체골수기질간세포이식술，우술전、술후1월、6월응용공능독립성측량(FIM)화신경공능결손평분진행공능성평분。결과환자술후6개월내림상증상호전유효솔체85%，무엄중병발증출현。수술치료1개월화6개월후FIM평분、신경공능결손평분여치료전상비명현승고，차이유통계학의의(P<0.05)，차수수방시간증가평분개선경명현。결론자체골수기질간세포이식치료가개선출혈성뇌졸중환자후유증，대우제고환자운동공능화생활질량유일정방조，단기장기료효잉수대양본다중심적림상연구진일보관찰。
Objective To investigate clinical effect of hemorrhagic cerebral apoplexy sequela treated with the application of autologous bone marrow stem cells transplantation. Methods 20 cases patients with hemorrhagic from 2011 January to 2012 June were treated with stereotactic technique for autologous bone marrow stem cell transplantation. The functional independence measure(FIM) functional score, NIHSS were evaluated before operation, 1month after operation and 6th month after operation. Results The clinical symptoms of patients with hemorrhagic stroke improved effective rate as to 85% whom without severe complications;surgical treatment for 1 month and 6 months later, FIM score and NIHSS were increased significantly compared with before treatment(P<0.05), with the more increase of follow-up time, the improvement is more obvious. Conclusion The autologous bone marrow stem cell transplantation therapy can improve the patients of hemorrhage sequelae stroke, motor function, the quality of life, but the clinical research on the long-term effects still needs a large sample multicenter further observation.