中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2014年
6期
385-389
,共5页
李珊珊%朱华群%栗占国%苏茵
李珊珊%硃華群%慄佔國%囌茵
리산산%주화군%률점국%소인
红斑狼疮,系统性%可溶性Mer受体酪氨酸激酶%狼疮肾炎%疾病活动度
紅斑狼瘡,繫統性%可溶性Mer受體酪氨痠激酶%狼瘡腎炎%疾病活動度
홍반랑창,계통성%가용성Mer수체락안산격매%랑창신염%질병활동도
Lupus erythematosus,systemic%Soluble Mer receptor tyrosine kinase%Lupus nephritis%Disease activity
目的 探讨可溶性Mer受体酪氨酸激酶(sMerTK)在SLE患者血清检测中的临床意义.方法 采用ELISA法分别检测101例SLE与96例疾病对照组患者,及62名健康对照组血清中sMerTK水平;分析比较其与SLE各种临床表现、实验室指标及疾病活动度的关系.采用t检验x2检验及Spearman相关分析法进行数据分析.结果 SLE患者血清中sMerTK水平[(10.6±6.0)ng/ml]明显高于疾病对照组[(4.4±2.0) ng/ml](t=9.704,P＜0.01)及健康对照组[(2.8±2.5)ng/ml] (t=1 1.505,P＜0.01).血清sMerTK浓度与SLE患者的性别、年龄、病程无关,与白细胞(r=-0.236,P=0.017)、血红蛋白(r=-0.354,P＜0.01)、血小板(r=-0.310,P=0.002)水平呈负相关.在伴有LN患者中,血清sMerTK水平[(11±6) ng/ml]高于不伴有LN的SLE患者[(9±6)ng/ml],差异具有统计学意义(t=2.071,P=0.041).sMerTK水平的高低与LN患者尿蛋白定量(24 h)(r=0.293,P=0.013)、血清肌酐(r=0.250,P=0.035)及肾小球滤过率(r=-0.201,P=0.045)的水平有相关性,与血清补体C3 (r=-0.447,P＜0.01)及补体C4(r=-0.357,P＜0.01)水平呈负相关,与抗dsDNA抗体(r=0.360,P＜0.01)、抗核小体抗体(AnuA) (r=0.264,P=0.016)及SLEDAI积分(r=0.473,P＜0.01)呈正相关.结论 SLE患者血清sMerTK水平明显升高,可能与患者的血液系统损害及LN相关,并提示狼疮病情活动.
目的 探討可溶性Mer受體酪氨痠激酶(sMerTK)在SLE患者血清檢測中的臨床意義.方法 採用ELISA法分彆檢測101例SLE與96例疾病對照組患者,及62名健康對照組血清中sMerTK水平;分析比較其與SLE各種臨床錶現、實驗室指標及疾病活動度的關繫.採用t檢驗x2檢驗及Spearman相關分析法進行數據分析.結果 SLE患者血清中sMerTK水平[(10.6±6.0)ng/ml]明顯高于疾病對照組[(4.4±2.0) ng/ml](t=9.704,P＜0.01)及健康對照組[(2.8±2.5)ng/ml] (t=1 1.505,P＜0.01).血清sMerTK濃度與SLE患者的性彆、年齡、病程無關,與白細胞(r=-0.236,P=0.017)、血紅蛋白(r=-0.354,P＜0.01)、血小闆(r=-0.310,P=0.002)水平呈負相關.在伴有LN患者中,血清sMerTK水平[(11±6) ng/ml]高于不伴有LN的SLE患者[(9±6)ng/ml],差異具有統計學意義(t=2.071,P=0.041).sMerTK水平的高低與LN患者尿蛋白定量(24 h)(r=0.293,P=0.013)、血清肌酐(r=0.250,P=0.035)及腎小毬濾過率(r=-0.201,P=0.045)的水平有相關性,與血清補體C3 (r=-0.447,P＜0.01)及補體C4(r=-0.357,P＜0.01)水平呈負相關,與抗dsDNA抗體(r=0.360,P＜0.01)、抗覈小體抗體(AnuA) (r=0.264,P=0.016)及SLEDAI積分(r=0.473,P＜0.01)呈正相關.結論 SLE患者血清sMerTK水平明顯升高,可能與患者的血液繫統損害及LN相關,併提示狼瘡病情活動.
목적 탐토가용성Mer수체락안산격매(sMerTK)재SLE환자혈청검측중적림상의의.방법 채용ELISA법분별검측101례SLE여96례질병대조조환자,급62명건강대조조혈청중sMerTK수평;분석비교기여SLE각충림상표현、실험실지표급질병활동도적관계.채용t검험x2검험급Spearman상관분석법진행수거분석.결과 SLE환자혈청중sMerTK수평[(10.6±6.0)ng/ml]명현고우질병대조조[(4.4±2.0) ng/ml](t=9.704,P＜0.01)급건강대조조[(2.8±2.5)ng/ml] (t=1 1.505,P＜0.01).혈청sMerTK농도여SLE환자적성별、년령、병정무관,여백세포(r=-0.236,P=0.017)、혈홍단백(r=-0.354,P＜0.01)、혈소판(r=-0.310,P=0.002)수평정부상관.재반유LN환자중,혈청sMerTK수평[(11±6) ng/ml]고우불반유LN적SLE환자[(9±6)ng/ml],차이구유통계학의의(t=2.071,P=0.041).sMerTK수평적고저여LN환자뇨단백정량(24 h)(r=0.293,P=0.013)、혈청기항(r=0.250,P=0.035)급신소구려과솔(r=-0.201,P=0.045)적수평유상관성,여혈청보체C3 (r=-0.447,P＜0.01)급보체C4(r=-0.357,P＜0.01)수평정부상관,여항dsDNA항체(r=0.360,P＜0.01)、항핵소체항체(AnuA) (r=0.264,P=0.016)급SLEDAI적분(r=0.473,P＜0.01)정정상관.결론 SLE환자혈청sMerTK수평명현승고,가능여환자적혈액계통손해급LN상관,병제시랑창병정활동.
Objective To investigate the clinical significance of soluble Mer receptor tyrosine kinase (sMerTK) in patients of systemic lupus erythematosus.Methods sMerTK was detected in the serum of 101 SLE patients,96 disease controls and 62 healthy controls (HC) by sandwich enzyme-linked immunosorbent assay (ELISA).The relationships between the serum levels of sMerTK and clinical manifestations,laboratory parameters,disease activity were investigated in SLE patients.Comparisons between groups were tested by t-test and x2 test,Correlation of parameters were analyzed by Spearman method.Results sMerTK levels in SLE patients [(10.6±6.0) ng/ml] was significantly higher than disease controls [(4.4±2.0) ng/ml] (t=9.704,P＜0.01) and healthy controls [(2.8±2.5) ng/ml] (t=11.505,P＜0.01).The concentrations in SLE patients were independent of gender,age and disease duration.The levels of sMerTK were negatively correlated with white blood cell (r=-0.236,P=0.017),hemaglobin(r=-0.354,P＜0.01),platelet values (r=-0.310,P=0.002).Compared with the patients without lupus nephritis (LN)[(9±6) ng/ml],patients with LN had higher concentrations in serum [(11±6) ng/ml],and the difference was statistically significant (t =2.071,P=0.041).In addition,sMerTK levels were also correlated with 24 h-urinary protein level (r=0.293,P=0.013),serum creatinine (r=0.250,P=0.035) and e-GFR (r=-0.201,P=0.045).Furthermore this study indicated that sMerTK was negatively correlated with C3 (r=-0.447,P＜0.01) and C4 (r=-0.357,P＜0.01)level,but positively correlated with anti-dsDNA antibody titers (r=0.360,P＜0.01),anti nucleosome antibody (AnuA) (r=0.264,P=0.016) and SLEDAI (r=0.473,P＜0.01).Conclusion sMerTK level is increased in SLE patients.The concentration may associate with hematology changes and lupus nephritis.It may be an indicator of disease activity.
