中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
22期
10084-10087
,共4页
温明哲%王杨%朱坤灿%庄步峰%王洪财%吴芳芳%段志新%马延斌
溫明哲%王楊%硃坤燦%莊步峰%王洪財%吳芳芳%段誌新%馬延斌
온명철%왕양%주곤찬%장보봉%왕홍재%오방방%단지신%마연빈
脑损伤%血气分析%创伤性轴索损伤%低氧血症
腦損傷%血氣分析%創傷性軸索損傷%低氧血癥
뇌손상%혈기분석%창상성축색손상%저양혈증
Brain injuries%Blood gas analysis%Traumatic axonal injury%Hyoxemia
目的:在创伤性轴索损伤(TAI)合并低氧血症性二次脑损伤(SBI)大鼠模型基础上进一步探讨不同氧浓度复苏对大鼠血气的影响。方法应用自制 TAI 致伤装置,大鼠伤后给予10%浓度氧吸入30 min制成低氧血症性SBI模型,随后给予大鼠不同氧浓度混合气体1 h,整个过程中监测大鼠不同氧浓度通气复苏后不同时间点血气变化情况。结果给予不同氧浓度气体复苏后,大鼠动脉氧分压和氧饱和度均升高,与缺氧时比较差异均有统计学意义(P<0.05);21%氧浓度组复苏后大鼠动脉氧分压和氧饱和度与致伤前一致(P>0.05),而50%、75%、100%氧浓度组复苏后与致伤前、21%氧浓度组相比较,大鼠动脉氧分压(P<0.05)和氧饱和度(P>0.05)均升高;并且21%、50%、75%、100%氧浓度组的动脉氧分压逐渐升高(P<0.05)。结论给氧治疗可以明显改善创伤后缺氧大鼠的动脉氧分压和氧饱和度,而且随着氧浓度的升高其动脉氧分压逐渐升高。
目的:在創傷性軸索損傷(TAI)閤併低氧血癥性二次腦損傷(SBI)大鼠模型基礎上進一步探討不同氧濃度複囌對大鼠血氣的影響。方法應用自製 TAI 緻傷裝置,大鼠傷後給予10%濃度氧吸入30 min製成低氧血癥性SBI模型,隨後給予大鼠不同氧濃度混閤氣體1 h,整箇過程中鑑測大鼠不同氧濃度通氣複囌後不同時間點血氣變化情況。結果給予不同氧濃度氣體複囌後,大鼠動脈氧分壓和氧飽和度均升高,與缺氧時比較差異均有統計學意義(P<0.05);21%氧濃度組複囌後大鼠動脈氧分壓和氧飽和度與緻傷前一緻(P>0.05),而50%、75%、100%氧濃度組複囌後與緻傷前、21%氧濃度組相比較,大鼠動脈氧分壓(P<0.05)和氧飽和度(P>0.05)均升高;併且21%、50%、75%、100%氧濃度組的動脈氧分壓逐漸升高(P<0.05)。結論給氧治療可以明顯改善創傷後缺氧大鼠的動脈氧分壓和氧飽和度,而且隨著氧濃度的升高其動脈氧分壓逐漸升高。
목적:재창상성축색손상(TAI)합병저양혈증성이차뇌손상(SBI)대서모형기출상진일보탐토불동양농도복소대대서혈기적영향。방법응용자제 TAI 치상장치,대서상후급여10%농도양흡입30 min제성저양혈증성SBI모형,수후급여대서불동양농도혼합기체1 h,정개과정중감측대서불동양농도통기복소후불동시간점혈기변화정황。결과급여불동양농도기체복소후,대서동맥양분압화양포화도균승고,여결양시비교차이균유통계학의의(P<0.05);21%양농도조복소후대서동맥양분압화양포화도여치상전일치(P>0.05),이50%、75%、100%양농도조복소후여치상전、21%양농도조상비교,대서동맥양분압(P<0.05)화양포화도(P>0.05)균승고;병차21%、50%、75%、100%양농도조적동맥양분압축점승고(P<0.05)。결론급양치료가이명현개선창상후결양대서적동맥양분압화양포화도,이차수착양농도적승고기동맥양분압축점승고。
Objective To explore the effects of different oxygen concentrations on the blood gases in the hypoxia-induced secondary brain injury(SBI) rat subjected to traumatic axonal injury(TAI). Methods TAI and systemic hypoxia was induced by an impact-acceleration&rotation device and ventilating rats with 10%oxygen in nitrogen 30 min, respectively. Adult Sprague-Dawley rats were randomly separated into four groups:A(21%O2), B(50%O2), C(75%O2), D(100%O2). After that the rats were given different concentrations of oxygen gas mixture 1 hour. Blood gas parameters (SpO2, PO2 and PCO2) among those groups were systemically assessed and compared. Results Given different oxygen concentrations gas, the PO2 and SPO2 of the rats were significantly increased compared with post-traumatic hypoxia. After resuscitation, the PO2 and SPO2 of A(21% O2) group consistent with before injury;While compared to before injury and A(21%O2) group, after resuscitation, the PO2 of B(50% O2), C(75% O2), D(100% O2) groups were significantly increased and the SPO2 increased with no statistically significant difference; the PO2 of B(50% O2), C(75% O2), D(100% O2) groups were gradually significantly increased. Conclusion Oxygen therapy can significantly improve the PO2 and SPO2 of the post-traumatic hypoxic rats, and with the increase of oxygen concentration, the PO2 was gradually increased.