CAJ | 학술논문

目的：探讨西北汉族原发性高血压患者并发症和β2肾上腺素能受体单核苷酸基因多态性的关系。方法采用院内交叉研究，共入选300例原发性高血压病患者，诊断标准为收缩压（SBP）/舒张压（DBP）≥140/90 mm Hg，既往有高血压史，目前正在使用抗高血压药物，现血压虽未达到上述水平，亦应诊断为原发性高血压。所有入选对象均参照此标准入组，用 Taqman PCR 方法测定β2肾上腺素能受体Gly16Arg和Glu27Gln两种多态性。观测了左心室肥大（CRT心电图及超声心动图方法）及心脏扩大情况（CTR，胸部X线片）。结果与其他基因型比较，Arg/Arg基因型的收缩压较高（P＝0.041＜0.05）。PWV在各基因型之间无统计学差异（P＞0.05）；与其他基因型相比，Gln27Gln基因型的反应性充血、心电图显示的左心室肥大及左心室质量指数均明显降低（P＜0.05）。心胸比率及 NTG 诱导的反应性充血在各组间也无明显变化（P＞0.05）。结论β2肾上腺素能受体Gly16Arg和Glu27Gln两种基因多态性与动脉硬化及心室重构具有一定关系。
목적：탐토서북한족원발성고혈압환자병발증화β2신상선소능수체단핵감산기인다태성적관계。방법채용원내교차연구，공입선300례원발성고혈압병환자，진단표준위수축압（SBP）/서장압（DBP）≥140/90 mm Hg，기왕유고혈압사，목전정재사용항고혈압약물，현혈압수미체도상술수평，역응진단위원발성고혈압。소유입선대상균삼조차표준입조，용 Taqman PCR 방법측정β2신상선소능수체Gly16Arg화Glu27Gln량충다태성。관측료좌심실비대（CRT심전도급초성심동도방법）급심장확대정황（CTR，흉부X선편）。결과여기타기인형비교，Arg/Arg기인형적수축압교고（P＝0.041＜0.05）。PWV재각기인형지간무통계학차이（P＞0.05）；여기타기인형상비，Gln27Gln기인형적반응성충혈、심전도현시적좌심실비대급좌심실질량지수균명현강저（P＜0.05）。심흉비솔급 NTG 유도적반응성충혈재각조간야무명현변화（P＞0.05）。결론β2신상선소능수체Gly16Arg화Glu27Gln량충기인다태성여동맥경화급심실중구구유일정관계。
Objective β2 adrenoreceptor is involved in the sympathetic nervous system, which plays an important role in the development of hypertension and hypertensive complications. These complications can include left ventricular hypertrophy and arterial stiffness, which are reported risk factors for cardiovascular diseases. We designed clinical trials to clarify the association between the hypertensive complications and β2 adrenoceptor single nucleotide polymorphisms in essential hypertension. Methods Using Taqman PCR methods, we detected two polymorphisms of β2 adrenoceptor Gly16Arg and Glu27Gln were detected using Taqman PCR methods. Three hundred subjects were included and measured pulse wave velocity, vasodilator response to hyperemia, left ventricular hypertrophy (by electrocardiogram and echocardiography), and cardiac enlargement (by chest X ray). Results Compared with other genotypes, the systolic pressure of Arg/Arg was higher (P=0.041,<0.05). PWV showed no difference among genotypes (P>0.05); The genotype Glu27Gln was found by both electrocardiogram and echocardiography significantly associated with left ventricular hypertrophy (P<0.05),and pulse wave velocity and nitroglycerin induced hyperemia were not found associated with these two polymorphisms. Conclusion These data suggested that two polymorphisms of β2 adrenoreceptor subtype Gly16Arg and Glu27Gln may have some genetic influences on atherosclerosis and ventricular remodeling in essential hypertension.