CAJ | 학술논문

目的：探讨内质网氨肽酶1（endoplasmic reticulum aminopeptidase 1，ERAP1）基因多态性与非小细胞肺癌（non-small cell lung cancer，NSCLC）的相关性。方法入选NSCLC患者224例，健康体检人群207例。采用Taq Man探针基因分型方法对ERAP1基因SNP rs26653和rs26618两个位点进行基因分型，并构建单倍型，评估上述两个SNPs及单倍型与NSCLC的相关性。结果病例组和对照组ERAP1基因rs26618和rs26653基因型和等位基因频率差异有统计学意义（P＜0.05）。病例组和对照组rs26618/rs26653单倍型CG、TC的单倍型频率差异有统计学意义（P＜0.05）。结论 ERAP1基因与NSCLC的发生有关， rs26618/rs26653-CG单倍型可能增加NSCLC的患病风险，rs26618/rs26653-TC单倍型对NSCLC可能具有保护性作用。
목적：탐토내질망안태매1（endoplasmic reticulum aminopeptidase 1，ERAP1）기인다태성여비소세포폐암（non-small cell lung cancer，NSCLC）적상관성。방법입선NSCLC환자224례，건강체검인군207례。채용Taq Man탐침기인분형방법대ERAP1기인SNP rs26653화rs26618량개위점진행기인분형，병구건단배형，평고상술량개SNPs급단배형여NSCLC적상관성。결과병례조화대조조ERAP1기인rs26618화rs26653기인형화등위기인빈솔차이유통계학의의（P＜0.05）。병례조화대조조rs26618/rs26653단배형CG、TC적단배형빈솔차이유통계학의의（P＜0.05）。결론 ERAP1기인여NSCLC적발생유관， rs26618/rs26653-CG단배형가능증가NSCLC적환병풍험，rs26618/rs26653-TC단배형대NSCLC가능구유보호성작용。
Objective To evaluate the association between the genetic polymorphisms of endoplasmic reticulum aminopeptidase 1 (ERAP1) and the susceptibility of non-small cell lung cancer (NSCLC) in Chinese Han population. Methods 224 patients with NSCLC and 207 healthy controls in Chinese Han were included in present study. Using TaqMan fluorescence probe technique, the SNPs of rs26618 and rs26653 in ERAP1 gene were genotyped, and rs26618 and rs26653 haplotypes were constructed. Then, the association between the two SNPs with NSCLC was assessed. Results The genotypic and allelic frequencies of rs26618, rs26653 showed significant difference between NSCLC patients and the control groups (all P<0.05). The frequencies of haplotype rs26618/rs26653-CG and TC also showed difference between NSCLC patients and the control groups (all P<0.05). Conclusion ERAP1 rs26618, rs26653 had a strong association with NSCLC. The rs26618/rs26653-CG haplotype was associated with increased NSCLC risk, whereas rs26618/rs26653-TC haplotype showed a protective effect in NSCLC patients.