CAJ | 학술논문

目的：观察不同时期及不同亚型偏头痛患者血清中过氧化物酶体增殖物激活受体γ（peroxisome proliferator-activated receptorγ，PPARγ）水平变化，探讨其与偏头痛的关系及临床意义。方法收集偏头痛患者105例，随机分成偏头痛发作期组（A 组，n＝47）和偏头痛发作间期组（B 组，n＝58），再根据患者有无先兆症状进一步分成四个亚组，同时选取100例健康者作为对照组。采用酶联免疫法（ELISA）检测受试者血清PPARγ水平，采用SPSS系统软件进行统计分析。结果偏头痛患者发作期PPARγ水平明显低于发作间期及健康对照者（P＜0.01）；发作间期的 PPARγ水平与健康对照者相比无明显统计学差异（P＞0.05）；有先兆与无先兆发作期PPARγ水平比较无明显差异（P＞0.05）；有先兆和无先兆发作间期PPARγ水平无明显统计学差异（P＞0.05）。结论偏头痛发作时血清PPARγ下调，其可能是偏头痛发病的潜在机制之一。有无先兆对PPARγ水平无明显影响。
목적：관찰불동시기급불동아형편두통환자혈청중과양화물매체증식물격활수체γ（peroxisome proliferator-activated receptorγ，PPARγ）수평변화，탐토기여편두통적관계급림상의의。방법수집편두통환자105례，수궤분성편두통발작기조（A 조，n＝47）화편두통발작간기조（B 조，n＝58），재근거환자유무선조증상진일보분성사개아조，동시선취100례건강자작위대조조。채용매련면역법（ELISA）검측수시자혈청PPARγ수평，채용SPSS계통연건진행통계분석。결과편두통환자발작기PPARγ수평명현저우발작간기급건강대조자（P＜0.01）；발작간기적 PPARγ수평여건강대조자상비무명현통계학차이（P＞0.05）；유선조여무선조발작기PPARγ수평비교무명현차이（P＞0.05）；유선조화무선조발작간기PPARγ수평무명현통계학차이（P＞0.05）。결론편두통발작시혈청PPARγ하조，기가능시편두통발병적잠재궤제지일。유무선조대PPARγ수평무명현영향。
Objective To investigate the PPARγlevel in serum and its relationship with migraine and clinical implications. Methods Hundred and five patients with migraine were divided into two main groups:attack period group (n=47) and attack free period group (n=58). According to the patients with or without aura symptoms patients were further divided into four subgroups. One hundred cases of healthy were taken as control. The serum levels of PPARγ were measured using enzyme-linked immunoassay (ELISA). Results The PPARγlevels in patients with migraine during headache attack period were significantly lower than those during headache free period and healthy control group (P<0.01). The PPARγ levels in headache free period had no significant difference to healthy control group (P>0.05). Conclusions Migraine inflammatory cells immune activation may be associated with lower PPARγ, and participate in the onset of migraine. The PPARγlevel reduction is one of the underlying mechanisms of migraine pathogenesis.