CAJ | 학술논문

通过构建小鼠温浴甩尾模型，研究不同给药方式下，蓝莓花青素的镇痛作用，并通过测量其一氧化碳（NO）含量和丙二醛（MDA）含量研究其可能的作用机制。结果表明，10 mg/kg蓝莓花青素能够延长小鼠疼痛的潜伏期，提高其抑制率；腹腔注射比皮下注射药物吸收速度更快；花青素能够减少大脑和血液中MDA的含量（P<0.05），同时，与空白组相比，NO的含量相应降低（P<0.05）。说明蓝莓花青素的镇痛效果可能与给药方式相关，其可能的作用机制与组织中MDA含量的降低及抑制NO的释放有关。
통과구건소서온욕솔미모형，연구불동급약방식하，람매화청소적진통작용，병통과측량기일양화탄（NO）함량화병이철（MDA）함량연구기가능적작용궤제。결과표명，10 mg/kg람매화청소능구연장소서동통적잠복기，제고기억제솔；복강주사비피하주사약물흡수속도경쾌；화청소능구감소대뇌화혈액중MDA적함량（P<0.05），동시，여공백조상비，NO적함량상응강저（P<0.05）。설명람매화청소적진통효과가능여급약방식상관，기가능적작용궤제여조직중MDA함량적강저급억제NO적석방유관。
Mice tail-immersion model were constructed to study the analgesic effect of anthocyanins (Ay) extracted from Blue Berry using different administrative pathways. Moreover , the concentration of nitric oxide (NO) and malonaldehyde (MDA) were measured to explore the underlying mechanism. Data revealed that 10 mg/kg Ay can effectively prolong the analgesic latency phase , the absorbance rate of intraperitoneal injection (i. p.) were faster than those of subcutaneous injection ( s.c), in addition, the effect of Ay can significantly reduce the content of NO and MDA in brain and serum (P<0.05). In conclusion, the administrative methods may attribute to the analgesic effect of Ay, probably related to the decrease of MDA and inhibition of NO release.