CAJ | 학술논문

目的：观察注射用复合辅酶对心脏瓣膜置换患者围术期的心肌保护作用。方法80例体外循环行心脏瓣膜置换的病人随机双盲分为对照组和辅酶组各40例，观察两组病人自动复跳情况，术后12h内心律失常的发生率，血浆磷酸激酸同工酶（CK-MB）、肌钙蛋白I（cTnI）的变化。结果两组病人心脏自动复跳率在辅酶组为85％，高于对照组67％（ P ＜0.05）。12 h内心律失常的发生率在辅酶组为26％，低于对照组38％（ P ＜0.05）。 CK-MB、cTnI的数值，在开放升主动脉10 min、手术结束、术后6h、术后12h，辅酶组均低于对照组（ P ＜0.05）。结论注射用复合辅酶用于体外循环心脏瓣膜置换病人，有确切的心肌保护作用。
목적：관찰주사용복합보매대심장판막치환환자위술기적심기보호작용。방법80례체외순배행심장판막치환적병인수궤쌍맹분위대조조화보매조각40례，관찰량조병인자동복도정황，술후12h내심률실상적발생솔，혈장린산격산동공매（CK-MB）、기개단백I（cTnI）적변화。결과량조병인심장자동복도솔재보매조위85％，고우대조조67％（ P ＜0.05）。12 h내심률실상적발생솔재보매조위26％，저우대조조38％（ P ＜0.05）。 CK-MB、cTnI적수치，재개방승주동맥10 min、수술결속、술후6h、술후12h，보매조균저우대조조（ P ＜0.05）。결론주사용복합보매용우체외순배심장판막치환병인，유학절적심기보호작용。
Objective To evaluate effection of the myocardial protective in treatment of coenzyme complex to the VR patients .Methods Eighty patients who need to VR were divided into control group ( n=40) and coenzyme complex group ( n =40) with double -blind.The automatic recovery rate of heart beats after cardiac resuscitation , the changes of postoperative arrhythmia rate , postoperative serum CK-MB, cTnI in 12h in two groups were recorded .Results The automatic recovery rate of heart beats was higher in coenzyme complex group than that in control group , (85%vs 67%, P <0.05).The changes of postopera-tive arrhythmia rate (26%vs 38%), serum CK-MB, cTnI at clamp off of aorta, end of operation,6hour of postoperation and 12 hour of postoperation were lower in coenzyme complex group than those in control group respectively ( all P <0.05 ) .Conclusion Coenzyme complex shows positive protection of myocardial in the VR patients.