CAJ | 학술논문

为了对黄连解毒散固体分散制剂进行药效学研究，采用致病性大肠杆菌和金黄色葡萄球菌为试验菌株考察黄连解毒散固体分散制剂的体外抑菌效果，以仔猪为实验动物考察其临床药效。结果显示：黄连解毒散固体分散制剂的体外抑菌效果是普通散剂的2倍，临床治疗效果比普通散剂提高了30％。黄连解毒散固体分散制剂显著提高了黄连解毒散对猪大肠杆菌病的疗效。
위료대황련해독산고체분산제제진행약효학연구，채용치병성대장간균화금황색포도구균위시험균주고찰황련해독산고체분산제제적체외억균효과，이자저위실험동물고찰기림상약효。결과현시：황련해독산고체분산제제적체외억균효과시보통산제적2배，림상치료효과비보통산제제고료30％。황련해독산고체분산제제현저제고료황련해독산대저대장간균병적료효。
The pharmacology of huanglian jiedu san solid dispersion preparation was researched. Pathogenic Escherichia coli and Staphylococcus aureus were used to examine the in vitro antibacterial effect of huanglian jiedu san solid dispersion preparation and piglets to investigate the clinical efficacy. Results indicated that the huanglian jiedu san solid dispersion preparation has twice the in vitro antibacterial effect and the clinical effect increased 30% compared with the common powder. Huanglian jiedu san solid dispersion preparation has more effect on piglets’ colibacillosis than that of pure drug.