中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
11期
1612-1614
,共3页
尖锐湿疣%5-氨基酮戊酸%光动力疗法%电灼术
尖銳濕疣%5-氨基酮戊痠%光動力療法%電灼術
첨예습우%5-안기동무산%광동력요법%전작술
Condylomata acuminata%5-aminolevulinic acid%Photodynamic therapy%Fulguration
目的 评价5-氨基酮戊酸光动力疗法(ALA-PDT)联合电灼术治疗肛周尖锐湿疣的疗效和复发率.方法 将67例肛周尖锐湿疣患者按门诊就诊顺序随机分为三组,联合治疗组22例用电灼术去除显性疣体后立即进行ALA-PDT治疗,每周1次,连续治疗3～4次;光动力组22例,用ALA-PDT治疗,每周1次,1个月为1个疗程;电灼术组23例,用传统方法电灼术对所有皮损逐个进行电灼气化治疗,每周1次的分批治疗,1个月为1个疗程.末次治疗后随访6个月判定疗效及观察复发率.结果 联合治疗组痊愈率为90.9％(20/22),复发率为9.1％ (2/22);光动力组痊愈率为54.5％ (12/22),复发率为22.7％ (5/22);电灼术组痊愈率为39.1％ (9/23),复发率为43.5％ (10/23).联合治疗组的痊愈率和复发率与电灼术治疗组差异有统计学意义(P =0.000;P =0.017).结论 ALA-PDT治疗肛周尖锐湿疣治愈率高,复发率低,副作用小.
目的 評價5-氨基酮戊痠光動力療法(ALA-PDT)聯閤電灼術治療肛週尖銳濕疣的療效和複髮率.方法 將67例肛週尖銳濕疣患者按門診就診順序隨機分為三組,聯閤治療組22例用電灼術去除顯性疣體後立即進行ALA-PDT治療,每週1次,連續治療3～4次;光動力組22例,用ALA-PDT治療,每週1次,1箇月為1箇療程;電灼術組23例,用傳統方法電灼術對所有皮損逐箇進行電灼氣化治療,每週1次的分批治療,1箇月為1箇療程.末次治療後隨訪6箇月判定療效及觀察複髮率.結果 聯閤治療組痊愈率為90.9％(20/22),複髮率為9.1％ (2/22);光動力組痊愈率為54.5％ (12/22),複髮率為22.7％ (5/22);電灼術組痊愈率為39.1％ (9/23),複髮率為43.5％ (10/23).聯閤治療組的痊愈率和複髮率與電灼術治療組差異有統計學意義(P =0.000;P =0.017).結論 ALA-PDT治療肛週尖銳濕疣治愈率高,複髮率低,副作用小.
목적 평개5-안기동무산광동력요법(ALA-PDT)연합전작술치료항주첨예습우적료효화복발솔.방법 장67례항주첨예습우환자안문진취진순서수궤분위삼조,연합치료조22례용전작술거제현성우체후립즉진행ALA-PDT치료,매주1차,련속치료3～4차;광동력조22례,용ALA-PDT치료,매주1차,1개월위1개료정;전작술조23례,용전통방법전작술대소유피손축개진행전작기화치료,매주1차적분비치료,1개월위1개료정.말차치료후수방6개월판정료효급관찰복발솔.결과 연합치료조전유솔위90.9％(20/22),복발솔위9.1％ (2/22);광동력조전유솔위54.5％ (12/22),복발솔위22.7％ (5/22);전작술조전유솔위39.1％ (9/23),복발솔위43.5％ (10/23).연합치료조적전유솔화복발솔여전작술치료조차이유통계학의의(P =0.000;P =0.017).결론 ALA-PDT치료항주첨예습우치유솔고,복발솔저,부작용소.
Objective To evaluate the relapse rate and the effect of 5-aminolevulinic acid photodynamic therapy(ALA-PDT) combined with fulguration in the treatment of perianal genital warts.Methods 67 patients with perianal genital warts were randomly divided into the three groups.22 cases in the fulguration and ALA-PDT treatment group performed the ALA-PDT treatment immediately after removal of dominant wart by fulguration,once a week,treatment for 3-4 times.22 cases in the ALA-PDT treatment group only underwent ALA-PDT treatment,once a week,treatment for one month.23 cases in the fulguration group were given the traditional fulguration methods one by one electrocautery fulguration gasification treatment for all skin lesions,a weekly batch treatment,treatment for a month.Follow-up six months after the last treatment to determine efficacy and recurrence rate.Results The cure rate of combined treatment group was 90.9％ (20/22),and recurrence rate was 9.1％ (2/22) ;cure rate of photodynamic group was 54.5％ (12/22),and its recurrence rate was 22.7％ (5/22) ; cure rate of fulguration group was 39.1％ (9/23),and the recurrence rate was 43.5％ (10/23).There were statistically significant differences in the cure rate and relapse rate between combination therapy group and electrocautery treatment group (P =0.000,P =0.017).Conclusion The fulguration combined with ALA-PDT in the treatment of perianal genital warts has high cure rate,low recurrence rate,and less side effects.
