CAJ | 학술논문

目的：观察扶正化瘀药软肝丸长程治疗对腹水型晚期血吸虫病（晚血）的疗效。方法收集54例腹水型晚血患者资料，按是否服用软肝丸分成治疗组及对照组，比较两组有效率、腹水消退、症状改善情况及血清白蛋白（ALB）和透明质酸（HA）水平改善的情况。结果治疗组有效率为92.59%，对照组有效率为44.44%，两组差异有统计学意义（P＜0.05）。治疗后9、12个月，治疗组腹水阴性者所占比例分别为77.78%和92.59%，症状改善例数所占比例分别为92.59%和96.30%，对照组腹水阴性者所占比例分别为29.63%和37.00%，症状改善例数所占比例分别为48.15%和51.85%；两组差异均有统计学意义（P均＜0.05）。治疗后9个月，治疗组ALB和HA水平正常者分别占88.89%和59.26%，对照组分别占40.74%和14.81%，两组差异均有统计学意义（P均＜0.05）。结论软肝丸长程治疗腹水型晚血可改善临床症状，控制腹水复发，但其更远期的疗效及复发率还有待进一步观察。
목적：관찰부정화어약연간환장정치료대복수형만기혈흡충병（만혈）적료효。방법수집54례복수형만혈환자자료，안시부복용연간환분성치료조급대조조，비교량조유효솔、복수소퇴、증상개선정황급혈청백단백（ALB）화투명질산（HA）수평개선적정황。결과치료조유효솔위92.59%，대조조유효솔위44.44%，량조차이유통계학의의（P＜0.05）。치료후9、12개월，치료조복수음성자소점비례분별위77.78%화92.59%，증상개선례수소점비례분별위92.59%화96.30%，대조조복수음성자소점비례분별위29.63%화37.00%，증상개선례수소점비례분별위48.15%화51.85%；량조차이균유통계학의의（P균＜0.05）。치료후9개월，치료조ALB화HA수평정상자분별점88.89%화59.26%，대조조분별점40.74%화14.81%，량조차이균유통계학의의（P균＜0.05）。결론연간환장정치료복수형만혈가개선림상증상，공제복수복발，단기경원기적료효급복발솔환유대진일보관찰。
Objective To evaluate the long-term therapeutic effect of Ruangan pills on advanced schistosomiasis combined with ascites. Methods The data of 54 advanced schistosomiasis patients with ascites were collected,and the patients were divid-ed into two groups namely a treatment group and a control group according to whether taking Ruangan pills. The effective rates,im-provement status of symptoms and levels of serum albumin(ALB)and hyaluronic acid(HA)of the two groups were compared. Re-sults The effective rates of the treatment group and control group were 92.59%and 44.44%,respectively,and the difference be-tween them was statistically significant(P<0.05). After the treatment for 9 and 12 months,the percentages of patients without as-cites and patients with symptom improvement in the treatment group were 77.78%and 92.59%,92.59%and 96.30%,respective-ly,while those in the control group were 29.63%and 37.00%,48.15%and 51.85%,respectively,and the differences between the two groups by different time were all statistical significant(all P<0.05). After the treatment for 9 months,the percentages of patients with the normal levels of ALB and HA were 88.89% and 59.26%,while those in the control group were 40.74% and 14.81%,respectively,and the differences between the two groups were statistically significant(both P < 0.05). Conclusion The long-term treatment of Ruangan pills can not only improve clinical symptoms but also control the ascites recurrence,however, the therapeutic effect and the recurrence rate of ascites in longer-term still need further observation.