CAJ | 학술논문

目的：探讨晚期血吸虫病肝纤维化程度与肝纤维化生化指标之间的相关性。方法以48例晚期血吸虫病肝病患者为研究对象，行肝活检及B超影像学检查，同时检测谷氨酰胺转肽酶（GGT）、碱性磷酸酶（AKP）、Ⅲ型前胶原（PC-Ⅲ）、Ⅳ型胶原（Ⅳ-C）、透明质酸（HA）及层粘连蛋白（LN）等肝纤维化生化指标。分别以肝活检病理结果和B超影像学检查确定肝纤维化程度，分析肝纤维化程度与上述肝纤维化生化指标间的相关性。结果肝活检病理检查确定的肝纤维化程度与各生化指标之间无相关性；B超影像学检查确定的肝纤维化程度与GGT、AKP、LN和PC-Ⅲ之间有一定相关性，与HA和Ⅳ-C呈显著相关。结论 B超检查是一种较好的无创性血吸虫病肝纤维化检查方法，结合肝纤维化生化指标能更好地反映肝脏整体状况。
목적：탐토만기혈흡충병간섬유화정도여간섬유화생화지표지간적상관성。방법이48례만기혈흡충병간병환자위연구대상，행간활검급B초영상학검사，동시검측곡안선알전태매（GGT）、감성린산매（AKP）、Ⅲ형전효원（PC-Ⅲ）、Ⅳ형효원（Ⅳ-C）、투명질산（HA）급층점련단백（LN）등간섬유화생화지표。분별이간활검병리결과화B초영상학검사학정간섬유화정도，분석간섬유화정도여상술간섬유화생화지표간적상관성。결과간활검병리검사학정적간섬유화정도여각생화지표지간무상관성；B초영상학검사학정적간섬유화정도여GGT、AKP、LN화PC-Ⅲ지간유일정상관성，여HA화Ⅳ-C정현저상관。결론 B초검사시일충교호적무창성혈흡충병간섬유화검사방법，결합간섬유화생화지표능경호지반영간장정체상황。
Objective To explore the correlation between the levels of liver fibrosis and liver fibrosis biochemical parameters of advanced schistosomiasis patients. Methods A total of 48 advanced schistosomiasis patients were investigated and they were examined by the liver biopsy and B ultrasound imaging. At the same time,the liver fibrosis biochemical parameters,including glu-tamine transpeptidase(GGT),alkaline phosphatase(AKP),procollagenⅢ(PC-Ⅲ),collagen typeⅣ(Ⅳ-C),hyaluronic acid (HA)and laminin(LN),were detected. The liver fibrosis levels were classified by the liver biopsy and B ultrasound imaging,re-spectively,and the correlation between the levels of liver fibrosis and liver fibrosis biochemical parameters were analyzed statisti-cally. Results There was no correlation between the liver fibrosis levels classified by the liver biopsy and all the liver fibrosis bio-chemical parameters;there was a weak correlation between the liver fibrosis levels classified by the B ultrasound imaging and GGT,AKP,LN and PC-Ⅲ,respectively;there was a significant correlation between the liver fibrosis levels classified by the B ul-trasound imaging and HA andⅣ-C,respectively. Conclusions B ultrasound examination is a better,noninvasive fibrosis in-spection method. Liver fibrosis biochemical parameters combined with the B ultrasound examination may better reflect the overall condition of liver fibrosis.