CAJ | 학술논문

背景与目的：乳腺癌是一组异质性的疾病，不同种族人群乳腺癌临床病理特征有所不同。本研究旨在探讨和比较上海汉族和新疆维吾尔族女性乳腺癌临床病理特征的异同点。方法：收集上海汉族女性浸润性导管癌125例，新疆维吾尔族女性浸润性导管癌85例，对两组人群临床特征、病理组织学分级和分子分型进行分析和比较。采用免疫组化检测ER、PR、HER-2、CK5/6、CK14、EGFR、Ki-67等的表达。结果：新疆维吾尔族女性乳腺癌发病的平均年龄低于上海汉族女性，且≤35岁的患者构成比高于上海汉族。上海汉族乳腺癌临床Ⅰ期的比例(20.0%)高于新疆维吾尔族(8.2%)，而新疆维吾尔族乳腺癌临床Ⅲ期的比例(50.6%)高于上海汉族(27.2%)。上海汉族乳腺癌组织学分级为2级的比例(67.2%)高于新疆维吾尔族(43.5%)，新疆维吾尔族乳腺癌组织学分级为3级的比例(47.1%)高于上海汉族(31.2%)。上海汉族女性腔面A型乳腺癌比例(36.8%)高于新疆维吾尔族(18.3%)，新疆维吾尔族女性基底样型乳腺癌比例(29.6%)高于上海汉族女性(12.0%)。乳腺癌分子分型与种族和组织学分级相关。结论：上海汉族和新疆维吾尔族女性乳腺癌的发病年龄、临床分期、组织学分级、分子分型等诸多临床病理特征均存在显著差异。
배경여목적：유선암시일조이질성적질병，불동충족인군유선암림상병리특정유소불동。본연구지재탐토화비교상해한족화신강유오이족녀성유선암림상병리특정적이동점。방법：수집상해한족녀성침윤성도관암125례，신강유오이족녀성침윤성도관암85례，대량조인군림상특정、병리조직학분급화분자분형진행분석화비교。채용면역조화검측ER、PR、HER-2、CK5/6、CK14、EGFR、Ki-67등적표체。결과：신강유오이족녀성유선암발병적평균년령저우상해한족녀성，차≤35세적환자구성비고우상해한족。상해한족유선암림상Ⅰ기적비례(20.0%)고우신강유오이족(8.2%)，이신강유오이족유선암림상Ⅲ기적비례(50.6%)고우상해한족(27.2%)。상해한족유선암조직학분급위2급적비례(67.2%)고우신강유오이족(43.5%)，신강유오이족유선암조직학분급위3급적비례(47.1%)고우상해한족(31.2%)。상해한족녀성강면A형유선암비례(36.8%)고우신강유오이족(18.3%)，신강유오이족녀성기저양형유선암비례(29.6%)고우상해한족녀성(12.0%)。유선암분자분형여충족화조직학분급상관。결론：상해한족화신강유오이족녀성유선암적발병년령、림상분기、조직학분급、분자분형등제다림상병리특정균존재현저차이。
Background and purpose: Breast cancer is a group of heterogeneous diseases which has racial disparities. Our study was to elucidate the clinicopathologic features of breast carcinoma in Shanghai Han and Xinjiang Uygur women and to analyze the racial differences. Methods: In this study, 125 cases of breast invasive ductal carcinoma of Shanghai Han women and 85 cases of Xinjiang Uygur women were collected. The clinical stage was analyzed. Histological grading was observed. Immunohistochemical staining of ER, PR, HER-2, CK5/6, CK14, EGFR, Ki-67 was performed. Molecular subtypes were studied. Results:The average age of onset of breast cancer in Xinjiang Uygur women was younger than in Shanghai Han women (P<0.05), and Xinjiang Uygur women were more likely to be diagnosed at less than 35 years old (P<0.01). The proportion of stageⅠwas higher in Shanghai Han women (20.0%vs 8.2%), while the proportion of stageⅢwas higher in Xinjiang Uygur women (50.6%vs 27.2%) (P<0.01). The proportion of grade 2 was higher in Shanghai Han women (67.2% vs 43.5%), while the proportion of grade 3 was higher in Xinjiang Uygur women (47.1%vs 31.2%) (P<0.01). The proportion of luminal A subtype was higher in Shanghai Han women (36.8%vs 18.3%), while the proportion of basal-like subtype was higher in Xinjiang Uygur women (29.6%vs 12.0%) (P<0.01). The molecular subtype was associated with race and histological grade (P<0.05).Conclusion:There are racial differences in clinicopathologic features of breast carcinoma between Shanghai Han and Xinjiang Uygur women.