微循环学杂志
微循環學雜誌
미순배학잡지
CHINESE JOURNAL OF MICROCIRCULATION
2014年
2期
42-45
,共4页
动脉硬化闭塞症%加味四妙勇安汤%前列腺素%E1%临床疗效
動脈硬化閉塞癥%加味四妙勇安湯%前列腺素%E1%臨床療效
동맥경화폐새증%가미사묘용안탕%전렬선소%E1%림상료효
Arteriosclerosis obliterans%Jia wei si miao yong an decoction%Prostaglandin E1%Clinical effects
目的：观察加味四妙勇安汤联合前列腺素 E1治疗下肢动脉硬化闭塞症(ASO)的临床疗效。方法：120例双侧下肢 ASO患者,以分层随机法分为两组,每组各60例。对照组用前列腺素 E120μg 静脉滴注,1次/天；治疗组在对照组治疗基础上,另口服加味四妙勇安汤,1剂/天,早晚各 1次。30天为1个疗程,共4个疗程。观察两组的临床疗效,并测定治疗前后白介素-17 A(IL-17 A)、全血表观黏度、血浆黏度、血浆纤维蛋白原(FIB)水平变化。结果：治疗组治疗后总有效率优于对照组(96.67% vs 68.33%,P<0.05)。两组治疗后 IL-17A、全血表观黏度、血浆黏度和 FIB水平(除对照组外)与治疗前比较,均有显著下降(P<0.05),治疗组较对照组更低(P<0.05)。结论：加味四妙勇安汤联合前列腺素 E1治疗下肢 ASO疗效明显,能有效降低炎性反应,改善患者血液流变性。
目的：觀察加味四妙勇安湯聯閤前列腺素 E1治療下肢動脈硬化閉塞癥(ASO)的臨床療效。方法：120例雙側下肢 ASO患者,以分層隨機法分為兩組,每組各60例。對照組用前列腺素 E120μg 靜脈滴註,1次/天；治療組在對照組治療基礎上,另口服加味四妙勇安湯,1劑/天,早晚各 1次。30天為1箇療程,共4箇療程。觀察兩組的臨床療效,併測定治療前後白介素-17 A(IL-17 A)、全血錶觀黏度、血漿黏度、血漿纖維蛋白原(FIB)水平變化。結果：治療組治療後總有效率優于對照組(96.67% vs 68.33%,P<0.05)。兩組治療後 IL-17A、全血錶觀黏度、血漿黏度和 FIB水平(除對照組外)與治療前比較,均有顯著下降(P<0.05),治療組較對照組更低(P<0.05)。結論：加味四妙勇安湯聯閤前列腺素 E1治療下肢 ASO療效明顯,能有效降低炎性反應,改善患者血液流變性。
목적：관찰가미사묘용안탕연합전렬선소 E1치료하지동맥경화폐새증(ASO)적림상료효。방법：120례쌍측하지 ASO환자,이분층수궤법분위량조,매조각60례。대조조용전렬선소 E120μg 정맥적주,1차/천；치료조재대조조치료기출상,령구복가미사묘용안탕,1제/천,조만각 1차。30천위1개료정,공4개료정。관찰량조적림상료효,병측정치료전후백개소-17 A(IL-17 A)、전혈표관점도、혈장점도、혈장섬유단백원(FIB)수평변화。결과：치료조치료후총유효솔우우대조조(96.67% vs 68.33%,P<0.05)。량조치료후 IL-17A、전혈표관점도、혈장점도화 FIB수평(제대조조외)여치료전비교,균유현저하강(P<0.05),치료조교대조조경저(P<0.05)。결론：가미사묘용안탕연합전렬선소 E1치료하지 ASO료효명현,능유효강저염성반응,개선환자혈액류변성。
Objective:To observe the clinical effects of Jia wei si miao yong an decoction combined with prostaglandin E1 in treating lower limb arteriosclerosis obliterans.Method:120 cases of bilateral lower limb arteriosclerosis obliterans were divided into two groups (60 cases each)by stratified random method.Patients in both groups were given 20 g prostaglandin E1 to intravenous drip,once a day.In addition,Patients in treatment group were given Jia wei si miao yong an decoction,which was one agent a day and be taken twice in the morning and evening.The treatment was 30 days a course,and 4 courses in total.Then we observed the clinical effects and measured interleukin 17A (IL-17A), apparent viscosity of whole blood,plasma viscosity,fibrinogen (FIB)level changes before and after treatment.Re-sults:The total effective rate of the treatment group was 96.67% compared with 68.33% of the control group (P<0.05);the levels of IL-17A,apparent viscosity of whole blood,plasma viscosity and FIB (except the control group) after treatment in the two groups were significantly lower than before the treatment (P<0.05);and the level of treatment group were lower than that of the control group (P<0.05).Conclusion:The clinical effects of Jia wei si miao yong an decoction combined with prostaglandin E1 in the treatment of lower limb arteriosclerosis obliterans was sure,it could obviously reduce the inflammatory reaction and effectively improve the index of blood rheology.
