CAJ | 학술논문

目的：观察放化同期治疗局部晚期非小细胞肺癌的近期疗效及外周血基质金属蛋白酶2(MMP 2)水平变化。方法：64例经病理确诊的ⅡB至ⅢB期的非小细胞肺癌患者,平分为成放化同期治疗组和放化序贯治疗组,两组均放疗42-49天,化疗约4个疗程,于治疗前1天、放疗第30天和疗程结束后,采用酶联免疫法检测外周血 MMP2表达水平并比较疗效。结果：两组总有效率分别为90.06%和68.8%,放化同期治疗组明显优于放化序贯治疗组(χ2=4.7300,P<0.05)。治疗前,两组 MMP2水平无显著性差异(t=0.369,P>0.05)。治疗30天到治疗结束,放化同期组 MMP 2水平逐渐下降,序贯组 MMP 2水平在治疗3 0天时升高,疗程结束后下降,均与治疗前比较有统计学意义(P<0.01)；放化同期组治疗30天的 MMP2水平明显低于序贯组(t=4.024,P<0.01),疗程结束后,两组 MMP2水平差异无显著性意义(t=0.469,P>0.05)。结论：放化同期治疗能够早期有效降低局部晚期非小细胞肺癌外周血 MMP 2水平,提高近期疗效。
목적：관찰방화동기치료국부만기비소세포폐암적근기료효급외주혈기질금속단백매2(MMP 2)수평변화。방법：64례경병리학진적ⅡB지ⅢB기적비소세포폐암환자,평분위성방화동기치료조화방화서관치료조,량조균방료42-49천,화료약4개료정,우치료전1천、방료제30천화료정결속후,채용매련면역법검측외주혈 MMP2표체수평병비교료효。결과：량조총유효솔분별위90.06%화68.8%,방화동기치료조명현우우방화서관치료조(χ2=4.7300,P<0.05)。치료전,량조 MMP2수평무현저성차이(t=0.369,P>0.05)。치료30천도치료결속,방화동기조 MMP 2수평축점하강,서관조 MMP 2수평재치료3 0천시승고,료정결속후하강,균여치료전비교유통계학의의(P<0.01)；방화동기조치료30천적 MMP2수평명현저우서관조(t=4.024,P<0.01),료정결속후,량조 MMP2수평차이무현저성의의(t=0.469,P>0.05)。결론：방화동기치료능구조기유효강저국부만기비소세포폐암외주혈 MMP 2수평,제고근기료효。
Objective:To observe the short-terum effect of concurrent chemoradiotherapy and sequential therapy and chan-ges of serum matrix metalloproteinases 2 (MMP2)in local advanced non-small cell lung cancer.Method:The 64 pa-tients with histologically confirmed non-small cell lung cancer were randomly divided into concurrent chemoradio-therapy group and sequential therapy group.Both groups received 42 to 49 days radiotherapy and about 4 cycles chemotherapy.Serum levels of MMP2 were measured with ELISA.Peripheral blood samples were taken before treatment,the thirtieth day and the end of treatment.At the same time to compare the curative effect.Results:The remission rates in two groups was 90.6% and 68.8% respectively;the effective rate of treatment in concurrent che-moradiotherapy group was better than that of sequential therapy group(χ2= 4.7300,P<0.05).There was no sig-nificant difference in serum levels of MMP2 between two groups before treatment(t=0.369,P>0.05).From the 30th day to the end of treatment,the level of MMP2 was gradually declined in concurrent chemoradiotherapy group, while in sequential therapy group it was increased significantly on the 30th day,decreased on the end of treatment. The two groups were compared with those before treatment had statistical significance(P<0.01).On the 30th day, MMP2 levels of concurrent chemoradiotherapy group were significantly lower than that of the sequential group(t=4.024,P<0.01),after the end of treatment,there was no significant difference of MMP2 levels in the two groups (t=0.469,P>0.05).Conclusion:Concurrent chemoradiotherapy can reduce MMP2 levels of the peripheral blood early in local advanced non small cell lung cancer and improve short-terum effect.