CAJ | 학술논문

目的：探讨犬胃壁植入125 I粒子后组织的放射性损伤。方法4只比格犬术中在胃体部植入125 I粒子（活度0．5 mCi，半衰期60．2 d）6枚，设计成平行两排，行距1．0 cm，每颗粒子间距1．0 cm，植入后CT扫描（层距2 mm），并以粒子外边缘为边界勾画感兴趣区域（ region of interest ，ROI），进行术后剂量验证，然后分别在1、2、3、4个半衰期时处死取材，主要观察大体标本，光镜下细胞组织学变化，电镜超微结构等变化。结果比格犬胃壁植入125 I放射性粒子在2个半衰期后出现放射性损伤最重，经过3个半衰期后损伤开始修复，4个半衰期后损伤已经固定并更进一步修复。结论比格犬胃壁合理分布植入125 I放射性粒子是安全可靠的。
목적：탐토견위벽식입125 I입자후조직적방사성손상。방법4지비격견술중재위체부식입125 I입자（활도0．5 mCi，반쇠기60．2 d）6매，설계성평행량배，행거1．0 cm，매과입자간거1．0 cm，식입후CT소묘（층거2 mm），병이입자외변연위변계구화감흥취구역（ region of interest ，ROI），진행술후제량험증，연후분별재1、2、3、4개반쇠기시처사취재，주요관찰대체표본，광경하세포조직학변화，전경초미결구등변화。결과비격견위벽식입125 I방사성입자재2개반쇠기후출현방사성손상최중，경과3개반쇠기후손상개시수복，4개반쇠기후손상이경고정병경진일보수복。결론비격견위벽합리분포식입125 I방사성입자시안전가고적。
Objective To investigate the stomach wall radiation damage after implantation of 125 I seeds. Methods Four Beagle dogs were intraoperatively implanted 6 125 I seeds in gastric body .The seeds were designed to distribute parallelly in two rows with 1.0 cm between two seeds and 1.0 cm between two rows.The activity of 125I seeds was 0.5 mCi and half-life was 60.2 days. After implantation, we employed CT scan (2 mm between each layer), and delineated the region of interest (ROI) by the outer edge of the boundary particle outline for postoperative dose verification , and dogs were sacrificed at 1, 2, 3, 4 half-lives respectively.We mainly observed gross specimen by naked eyes , cell histological changes under optical microscope , and ultrastructural changes under electron microscopy . Results The radioactive damage occurred most severely after two half-lives since 125 I seeds ’ implantation in stomach wall;after three half-lives, the injury began to recover and after four half-lives, the damages did not expand and were further repaired. Conclusion Reasonable distribution and implantation of 125 I seeds in Beagle dogs stomach wall is safe and reliable .