中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
7期
1347-1350
,共4页
缺血%血视网膜屏障%炎症%抗炎药物
缺血%血視網膜屏障%炎癥%抗炎藥物
결혈%혈시망막병장%염증%항염약물
Ischemia%Blood-retinal barrier%Inflammatory%Anti-inflammatory drug
缺血缺氧性血-视网膜屏障（BRB）损伤是许多眼病和某些全身疾病所共有的病理损害，严重损害患者视力。BRB损伤的发病机制目前尚不明确，近年来有文献报道，炎症反应以及血管内皮生长因子（VEGF）、色素上皮源性生长因子（PEDF）、细胞间黏附因子-1（ICAM-1）、白细胞介素（IL）和肿瘤坏死因子-α（TNF-α）等炎性因子与该病变的发生发展密切相关，应用糖皮质激素、抗VEGF抗体、非甾体类抗炎药（NSAIDs）、褪黑激素抑制炎症反应过程为保护BRB开辟了新的途径。本文就缺血缺氧性BRB炎症损伤机制及利用抑制炎症反应及炎性因子的方法治疗BRB损伤的机制进行综述。
缺血缺氧性血-視網膜屏障（BRB）損傷是許多眼病和某些全身疾病所共有的病理損害，嚴重損害患者視力。BRB損傷的髮病機製目前尚不明確，近年來有文獻報道，炎癥反應以及血管內皮生長因子（VEGF）、色素上皮源性生長因子（PEDF）、細胞間黏附因子-1（ICAM-1）、白細胞介素（IL）和腫瘤壞死因子-α（TNF-α）等炎性因子與該病變的髮生髮展密切相關，應用糖皮質激素、抗VEGF抗體、非甾體類抗炎藥（NSAIDs）、褪黑激素抑製炎癥反應過程為保護BRB開闢瞭新的途徑。本文就缺血缺氧性BRB炎癥損傷機製及利用抑製炎癥反應及炎性因子的方法治療BRB損傷的機製進行綜述。
결혈결양성혈-시망막병장（BRB）손상시허다안병화모사전신질병소공유적병리손해，엄중손해환자시력。BRB손상적발병궤제목전상불명학，근년래유문헌보도，염증반응이급혈관내피생장인자（VEGF）、색소상피원성생장인자（PEDF）、세포간점부인자-1（ICAM-1）、백세포개소（IL）화종류배사인자-α（TNF-α）등염성인자여해병변적발생발전밀절상관，응용당피질격소、항VEGF항체、비치체류항염약（NSAIDs）、퇴흑격소억제염증반응과정위보호BRB개벽료신적도경。본문취결혈결양성BRB염증손상궤제급이용억제염증반응급염성인자적방법치료BRB손상적궤제진행종술。
Loss of the hypoxic-ischemic blood-retinal barrier (BRB) is the common pathology of a wide number of retinal diseases and some general diseases, which seriously affects visual acuity. Although the actual mechanism of BRB damage is not yet completely clear, mounting evidence suggests that the development of BRB damage may be associated with inflammatory processes and inflammatory factors, such as vascular endothelial growth factor (VEGF), pigment epithelium derived growth factor (PEDF), intercellular adhesion molecule-1 (ICAM-1), interleukin, tumor necrosis factor-α(TNF-α). Usage of glucocorticoids, anti-VEGF agents, nonsteroidal anti-inflammatory drugs (NSAIDs) and melatonin to inhibit inflammatory process would be a new approach to protect the BRB.This article reviews the current studies about the effects of inflammatory reaction and inflammatory factor in the pathogenesis of hypoxic-ischemic BRB damage, mechanism of suppressing inflammatory response and anti-inflammatory factor in the treatment of hypoxic-ischemic BRB damage.
