中国产前诊断杂志（电子版）
中國產前診斷雜誌（電子版）
중국산전진단잡지（전자판）
CHINESE JOURNAL OF PRENATAL DIAGNOSIS(ELECTRONIC VERSION)
2014年
1期
27-32
,共6页
黄丽娟%赖峥菲%陈敏%刘维瑜%王佳燕
黃麗娟%賴崢菲%陳敏%劉維瑜%王佳燕
황려연%뢰쟁비%진민%류유유%왕가연
早孕期%比较基因组杂交技术%孕妇%健康教育
早孕期%比較基因組雜交技術%孕婦%健康教育
조잉기%비교기인조잡교기술%잉부%건강교육
first trimester%comparative genomic hybridization%pregnancy%health education
目的：为了解孕妇对胎儿基因芯片技术的认知现状，以便更好地做好孕妇产前诊断的健康教育需求分析。方法使用一个由18个问题构成的调查表，调查孕妇对胎儿基因芯片技术的认知现状认知倾向。结果在250份调查问卷中，55．3％孕妇进行过产前诊断，其中13．5％的孕妇曾经引产过异常胎儿，12．5％的孕妇曾孕育分娩智力低下、生长发育迟缓的患儿，17％有不明原因的死胎、死产、新生儿死亡的不良孕产史，14％具有不明原因的遗传病或染色体异常家族史，34．6％进行过染色体核型分析，51％孕妇错误地认为染色体核型分析可以发现所有的染色体异常，12．3％曾了解胎儿基因芯片知识，5．6％孕妇知道胎儿基因芯片可以检测染色体核型分析中检测不到的微缺失或微重复，4．5％孕妇知道染色体的微缺失或微重复可导致智力低下、生长发育迟缓、器官畸形及功能障碍。仅有9．8％孕妇表示若超声提示胎儿结构异常而染色体核型正常，愿意进行胎儿基因芯片的检测，85％的孕妇不知道目前运用的“胎儿基因芯片”可以检测100种以上的综合征，66．3％的孕妇错误地认为胎儿基因芯片检测报告正常，就意味着胎儿绝对正常。结论孕妇对胎儿基因芯片技术认识明显不够，需在孕前或早孕期教育等时机予以普及，这对防止医疗新技术应用中由于结果和期望值落差造成的医患纠纷。
目的：為瞭解孕婦對胎兒基因芯片技術的認知現狀，以便更好地做好孕婦產前診斷的健康教育需求分析。方法使用一箇由18箇問題構成的調查錶，調查孕婦對胎兒基因芯片技術的認知現狀認知傾嚮。結果在250份調查問捲中，55．3％孕婦進行過產前診斷，其中13．5％的孕婦曾經引產過異常胎兒，12．5％的孕婦曾孕育分娩智力低下、生長髮育遲緩的患兒，17％有不明原因的死胎、死產、新生兒死亡的不良孕產史，14％具有不明原因的遺傳病或染色體異常傢族史，34．6％進行過染色體覈型分析，51％孕婦錯誤地認為染色體覈型分析可以髮現所有的染色體異常，12．3％曾瞭解胎兒基因芯片知識，5．6％孕婦知道胎兒基因芯片可以檢測染色體覈型分析中檢測不到的微缺失或微重複，4．5％孕婦知道染色體的微缺失或微重複可導緻智力低下、生長髮育遲緩、器官畸形及功能障礙。僅有9．8％孕婦錶示若超聲提示胎兒結構異常而染色體覈型正常，願意進行胎兒基因芯片的檢測，85％的孕婦不知道目前運用的“胎兒基因芯片”可以檢測100種以上的綜閤徵，66．3％的孕婦錯誤地認為胎兒基因芯片檢測報告正常，就意味著胎兒絕對正常。結論孕婦對胎兒基因芯片技術認識明顯不夠，需在孕前或早孕期教育等時機予以普及，這對防止醫療新技術應用中由于結果和期望值落差造成的醫患糾紛。
목적：위료해잉부대태인기인심편기술적인지현상，이편경호지주호잉부산전진단적건강교육수구분석。방법사용일개유18개문제구성적조사표，조사잉부대태인기인심편기술적인지현상인지경향。결과재250빈조사문권중，55．3％잉부진행과산전진단，기중13．5％적잉부증경인산과이상태인，12．5％적잉부증잉육분면지력저하、생장발육지완적환인，17％유불명원인적사태、사산、신생인사망적불량잉산사，14％구유불명원인적유전병혹염색체이상가족사，34．6％진행과염색체핵형분석，51％잉부착오지인위염색체핵형분석가이발현소유적염색체이상，12．3％증료해태인기인심편지식，5．6％잉부지도태인기인심편가이검측염색체핵형분석중검측불도적미결실혹미중복，4．5％잉부지도염색체적미결실혹미중복가도치지력저하、생장발육지완、기관기형급공능장애。부유9．8％잉부표시약초성제시태인결구이상이염색체핵형정상，원의진행태인기인심편적검측，85％적잉부불지도목전운용적“태인기인심편”가이검측100충이상적종합정，66．3％적잉부착오지인위태인기인심편검측보고정상，취의미착태인절대정상。결론잉부대태인기인심편기술인식명현불구，수재잉전혹조잉기교육등시궤여이보급，저대방지의료신기술응용중유우결과화기망치락차조성적의환규분。
Objective Understanding the cognitive status of maternal fetal DNA microarray technology, so it can do a better job of health education needs of pregnant women during first trimester in prenatal di-agnostic.Method Using a questionnaire consisting of 18 questions in order to investigate the cognitive status and tendency of the pregnant on fetal DNA microarray technology.Results In the 250 copies of the questionnaire who have done,55.3% of them had a prenatal diagnosis,13.5% of them had an abortion because of the abnormal fetuses,12.5% of them had given birth a baby who had mental retardation and growth retardation,1 7% of them had an adverse pregnancy history of unexplained stillbirth and neonatal death,14% of them had an unexplained family history of genetic disease or chromosomal abnormalities, 34.6% of them conducted a karyotype analysis,51% of these pregnant women believe that all chromo-somal abnormalities can be found by karyotype analysis mistakenly.1 2 .3% had the knowledge of the fetal DNA chip,but only 5 .6% of them know that fetal DNA chip can detect the DNA microdeletions and mi-crorepeat which the karyotype analysis not.Only 4 .5% of the women had the knowledge that DNA mi-crodeletions and microrepeat may leat to mental retardation,growth retardation,organ deformities and dysfunction.Of which the women who had done the questionnaire,only 9 .8% of them who had the fetal structural abnormalities ultrasonic but the normal karyotype,willing to detect fetal chip,85%of the preg-nant women didn’t know the current chip can detect more than 100 kind of disease syndromes,663% of the women believed that a normal report of the fetal DNA chip mean an absolutely normal fetus. Conclusion It is not enough for the maternal women to understand the fetal DNA microarray technology, it needs more and more women to understand the health education in the pre-pregnancy or the first trimes-ter.This measure can guide the pregnant women what to do in the time of pregnancy,so that it can help the women who had a abnormal baby conducted a prenatal diagnosis in the first trimester,avoid the birth defects and reduce the gap between the expectation and the result of a healthy baby which cause the patient disputes.
