检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2014年
9期
1210-1212
,共3页
脑钠肽%急性冠状动脉综合征%主要心血管不良事件
腦鈉肽%急性冠狀動脈綜閤徵%主要心血管不良事件
뇌납태%급성관상동맥종합정%주요심혈관불량사건
brain natriuretic peptide%acute coronary syndrome%major adverse cardiovascular events
目的：探讨血浆脑钠肽（BNP）与急性冠状动脉综合征（ACS）患者发生主要不良心血管事件（MACE）的相关性。方法收集该院就诊的ACS患者210例，检查住院期间的BNP ，并记录住院期间和出院后30 d MACE的发生情况。根据BNP的不同，把ACS患者分成两组（A组：BNP＜100 pg/mL ；B组：BNP≥100 pg/mL），比较两组患者发生MACE的差异。结果 B组患者的平均年龄为（65．9±11．4）岁，明显高于A组的（62．6±10．3）岁（P＝0．03）；B组S T段抬高型心肌梗死患者占53．7％，高于A组的34．3％（ P＝0．005）；两组患者在性别、糖尿病、高血压、血脂异常和吸烟史等方面差异无统计学意义（P＞0．05）。住院期间，B组MACE的发生率为17．6％，明显高于A组的4．9％（P＝0．004）；B组心因性病死率和再发心肌梗死率均明显高于A组（P＜0．05）。入院至出院后1个月，B组MACE的发生率为33．3％，明显高于A组的9．8％（P＜0．01）；B组心因性病死率、再发心肌梗死率和再次血运重建率均明显高于A组（P＜0．05）。结论血浆BNP水平的增高，增加ACS患者短期MACE的发生率。临床上对BNP＞100 pg/mL的ACS患者应给予更多的关注。
目的：探討血漿腦鈉肽（BNP）與急性冠狀動脈綜閤徵（ACS）患者髮生主要不良心血管事件（MACE）的相關性。方法收集該院就診的ACS患者210例，檢查住院期間的BNP ，併記錄住院期間和齣院後30 d MACE的髮生情況。根據BNP的不同，把ACS患者分成兩組（A組：BNP＜100 pg/mL ；B組：BNP≥100 pg/mL），比較兩組患者髮生MACE的差異。結果 B組患者的平均年齡為（65．9±11．4）歲，明顯高于A組的（62．6±10．3）歲（P＝0．03）；B組S T段抬高型心肌梗死患者佔53．7％，高于A組的34．3％（ P＝0．005）；兩組患者在性彆、糖尿病、高血壓、血脂異常和吸煙史等方麵差異無統計學意義（P＞0．05）。住院期間，B組MACE的髮生率為17．6％，明顯高于A組的4．9％（P＝0．004）；B組心因性病死率和再髮心肌梗死率均明顯高于A組（P＜0．05）。入院至齣院後1箇月，B組MACE的髮生率為33．3％，明顯高于A組的9．8％（P＜0．01）；B組心因性病死率、再髮心肌梗死率和再次血運重建率均明顯高于A組（P＜0．05）。結論血漿BNP水平的增高，增加ACS患者短期MACE的髮生率。臨床上對BNP＞100 pg/mL的ACS患者應給予更多的關註。
목적：탐토혈장뇌납태（BNP）여급성관상동맥종합정（ACS）환자발생주요불양심혈관사건（MACE）적상관성。방법수집해원취진적ACS환자210례，검사주원기간적BNP ，병기록주원기간화출원후30 d MACE적발생정황。근거BNP적불동，파ACS환자분성량조（A조：BNP＜100 pg/mL ；B조：BNP≥100 pg/mL），비교량조환자발생MACE적차이。결과 B조환자적평균년령위（65．9±11．4）세，명현고우A조적（62．6±10．3）세（P＝0．03）；B조S T단태고형심기경사환자점53．7％，고우A조적34．3％（ P＝0．005）；량조환자재성별、당뇨병、고혈압、혈지이상화흡연사등방면차이무통계학의의（P＞0．05）。주원기간，B조MACE적발생솔위17．6％，명현고우A조적4．9％（P＝0．004）；B조심인성병사솔화재발심기경사솔균명현고우A조（P＜0．05）。입원지출원후1개월，B조MACE적발생솔위33．3％，명현고우A조적9．8％（P＜0．01）；B조심인성병사솔、재발심기경사솔화재차혈운중건솔균명현고우A조（P＜0．05）。결론혈장BNP수평적증고，증가ACS환자단기MACE적발생솔。림상상대BNP＞100 pg/mL적ACS환자응급여경다적관주。
Objective To investigate the relationship between brain natriuretic peptide (BNP) and major ad-verse cardiovascular events(MACE) in acute coronary syndrome(ACS) patients .Methods Two hundred and ten ACS patients ,treated in this hospital ,were enrolled .Plasma BNP was detected ,and MACE during hospitalization and within 30 days after discharging were collected .According to plasma BNP level ,all patients were divided into group A ,with BNP<100 pg/mL ,and group B ,with BNP≥100 pg/mL .MACE were compared between the two groups .Re-sults The mean age of group B was (65 .9 ± 11 .4)years ,which was significantly higher than the (62 .6 ± 10 .3)years of group A(P=0 .03) .The proportion of patients with ST segment elevation myocardial infarction (STEMI) in group B was 53 .7% ,which was significantly higher than the 34 .3% in group A(P=0 .005) .However ,the differences of sex ,diabetes ,hypertension ,dyslipidemia and smoking were not statistically significant (P>0 .05) .During hospitaliza-tion ,incidence rate of MACE in group B was 17 .6% ,which was higher than the 4 .9% of group A(P=0 .004) ,and cardiac mortality and recurrence of myocardial infarction in group B were also higher than group A (P<0 .05) .One-month after discharging ,incidence rate of MACE in group B was 33 .3% ,which was higher than the 9 .8% in group A(P<0 .01) ,and cardiac mortality ,recurrence of myocardial infarction and re-revascularization of group B were also higher than group A(P<0 .05) .Conclusion Incidence rate of short-term MACE might be increased in ACS patients with the increasing of plasma BNP levels .To ACS patients with BNP≥100 pg/mL ,more attention should be paid in clinical works .
