化学研究与应用
化學研究與應用
화학연구여응용
CHEMICAL RESEARCH AND APPLICATION
2014年
1期
117-120
,共4页
环二肽%环(L-色-L-脯)衍生物%吲哚生物碱%抑菌活性
環二肽%環(L-色-L-脯)衍生物%吲哚生物堿%抑菌活性
배이태%배(L-색-L-포)연생물%신타생물감%억균활성
cyclic dipeptide%cyclo( L-Trp-L-Pro) derivative%indolyl alkaloid%antibacterial activity
以L-色氨酸甲酯盐酸盐、芳香醛和N-Fmoc-L-脯氨酸为原料,经过Pictet-Spengler反应、Schotten-Baumann反应、NBS开环反应、碱催化增环反应,得到4个环( L-色-L-脯)的衍生物,其结构均经过熔点测定、NMR、元素分析表征。在抑菌活性测试中发现,该类化合物对细菌有较好的抑制活性。
以L-色氨痠甲酯鹽痠鹽、芳香醛和N-Fmoc-L-脯氨痠為原料,經過Pictet-Spengler反應、Schotten-Baumann反應、NBS開環反應、堿催化增環反應,得到4箇環( L-色-L-脯)的衍生物,其結構均經過鎔點測定、NMR、元素分析錶徵。在抑菌活性測試中髮現,該類化閤物對細菌有較好的抑製活性。
이L-색안산갑지염산염、방향철화N-Fmoc-L-포안산위원료,경과Pictet-Spengler반응、Schotten-Baumann반응、NBS개배반응、감최화증배반응,득도4개배( L-색-L-포)적연생물,기결구균경과용점측정、NMR、원소분석표정。재억균활성측시중발현,해류화합물대세균유교호적억제활성。
Four cyclo(L-Trp-L-Pro)derivatives were synthesized starting with methyl L-tryptophanate hydrochloride,aromatic alde-hydes and N-Fmoc-L-proline through Pictet-Spengler reaction,Schotten-Baumann reaction,NBS ring-opening and base catalyzed an-nelation. The structures were characterized by m. p. tests,NMR spectrum and elemental analysis. All compounds were shown good activity against bacteria according to the antimicrobial activities test.