CAJ | 학술논문

目的：探讨牙周基础治疗对伴2型糖尿病的中、重度牙周炎患者牙周炎症控制、血清炎症指标以及糖代谢水平的影响。方法将前期临床试验人群中的56例中、重度牙周炎患者（平均临床附着水平>3 mm）纳入本研究进行亚组分析，采用重复测量的方差分析比较治疗组和对照组牙周指数（包括平均探诊深度、临床附着水平和探诊出血指数）、超敏C反应蛋白（hsCRP）、糖化血红蛋白（HbA1c）、空腹血糖在基线、1.5个月、3个月、6个月连续4次的变化。结果伴2型糖尿病的中、重度牙周炎患者在牙周治疗后平均探诊深度（F=62.898，P=0.000）、临床附着水平（F=51.263，P=0.000）和探诊出血指数（F=75.164，P=0.000）在治疗后逐渐改善，其中平均探诊深度（t=-2.050，P=0.045）和探诊出血指数（t=-4.538，P=0.000）显著优于对照组；治疗后hsCRP（F=6.391，P=0.010）、HbA1c（F=4.536，P=0.011）、空腹血糖（F=3.073，P=0.031）降低，其中hsCRP显著低于对照组（t=-2.261，P=0.028）。结论牙周基础治疗有助于改善伴2型糖尿病的中、重度牙周炎患者的牙周炎症和血清炎症指标以及糖代谢水平。
목적：탐토아주기출치료대반2형당뇨병적중、중도아주염환자아주염증공제、혈청염증지표이급당대사수평적영향。방법장전기림상시험인군중적56례중、중도아주염환자（평균림상부착수평>3 mm）납입본연구진행아조분석，채용중복측량적방차분석비교치료조화대조조아주지수（포괄평균탐진심도、림상부착수평화탐진출혈지수）、초민C반응단백（hsCRP）、당화혈홍단백（HbA1c）、공복혈당재기선、1.5개월、3개월、6개월련속4차적변화。결과반2형당뇨병적중、중도아주염환자재아주치료후평균탐진심도（F=62.898，P=0.000）、림상부착수평（F=51.263，P=0.000）화탐진출혈지수（F=75.164，P=0.000）재치료후축점개선，기중평균탐진심도（t=-2.050，P=0.045）화탐진출혈지수（t=-4.538，P=0.000）현저우우대조조；치료후hsCRP（F=6.391，P=0.010）、HbA1c（F=4.536，P=0.011）、공복혈당（F=3.073，P=0.031）강저，기중hsCRP현저저우대조조（t=-2.261，P=0.028）。결론아주기출치료유조우개선반2형당뇨병적중、중도아주염환자적아주염증화혈청염증지표이급당대사수평。
Objective To evaluate the effects of periodontal treatment on the clinical response, systemic inflammatory parameters, and metabolic control of type 2 diabetes patients with moderate to severe periodontitis. Methods A total of 56 patients with mean clinical attachment level (CAL)>3 mm were included in the subgroup analysis. A repeated-measures ANOVA (group factor: treatment group and control group; time factor: initial visit, 1.5, 3, and 6 months) was used to analyze the probing depth (PD), CAL, bleeding on probing (BOP), high-sensitivity C-reactive protein (hsCRP), glycated hemoglobin (HbA1c), and fasting plasma glucose. Results Significantly lower PD (F=62.898,P=0.000), CAL (F=51.263,P=0.000), BOP (F=75.164,P=0.000), hsCRP (F=6.391, P=0.010), HbA1c (F=4.536, P=0.011), and fasting plasma glucose level (F=3.073,P=0.031) were observed after therapeutic periodontal improvement. The inter-group differences for PD (t=-2.050, P=0.045), BOP (t=-4.538,P=0.000), and hsCRP (t=-2.261, P=0.028) were statistically significant after therapy. Conclusion Non-surgical periodontal treatment can effectively improve periodontal status, circulating inflammatory status, and metabolic control of diabetic patients with moderate to severe periodontitis.