基层医学论坛
基層醫學論罈
기층의학론단
PUBLIC MEDICAL FORUM MAGAZINE
2014年
1期
20-22
,共3页
血吸虫病%结直肠癌%结直肠炎%TGF-α%预后
血吸蟲病%結直腸癌%結直腸炎%TGF-α%預後
혈흡충병%결직장암%결직장염%TGF-α%예후
Schistosomiasis%Colorectal cancer%Colorectal inflammation%TGF-α%Prognosis
目的：探讨检测血吸虫病结直肠癌转化生长因子-α血清浓度的临床意义。方法对2009年7月-2012年7月因慢性腹泻或伴有血便或黏液便，来我院做肠镜检查证实为血吸虫病结直肠癌的48例患者（试验组）术前、术后做血清转化生长因子-α（TGF-α）测定，并以同期因慢性腹泻做肠镜检查证实为慢性血吸虫病结直肠炎患者40例（对照组）的血清TGF-α进行对比，2组患者均采用酶联免疫吸附试验进行检测。结果血吸虫病结直肠癌患者的血清TGF-α浓度（296±99）pg/mL较血吸虫病结肠炎患者高（167±28）pg/mL （P<0.01）。结直肠癌患者的血清TGF-α浓度与肿瘤分期、肿瘤大小无关（P>0.05），与肿瘤组织学分类呈正相关（P<0.05），根治术后血清TGF-α浓度较术前明显下降（P<0.05），姑息术后血清TGF-α浓度与术前浓度无差异（P>0.05）。结论结直肠癌患者血清TGF-α浓度可作为判断结直肠癌恶性程度和肿瘤是否根治的一项临床指标。
目的：探討檢測血吸蟲病結直腸癌轉化生長因子-α血清濃度的臨床意義。方法對2009年7月-2012年7月因慢性腹瀉或伴有血便或黏液便，來我院做腸鏡檢查證實為血吸蟲病結直腸癌的48例患者（試驗組）術前、術後做血清轉化生長因子-α（TGF-α）測定，併以同期因慢性腹瀉做腸鏡檢查證實為慢性血吸蟲病結直腸炎患者40例（對照組）的血清TGF-α進行對比，2組患者均採用酶聯免疫吸附試驗進行檢測。結果血吸蟲病結直腸癌患者的血清TGF-α濃度（296±99）pg/mL較血吸蟲病結腸炎患者高（167±28）pg/mL （P<0.01）。結直腸癌患者的血清TGF-α濃度與腫瘤分期、腫瘤大小無關（P>0.05），與腫瘤組織學分類呈正相關（P<0.05），根治術後血清TGF-α濃度較術前明顯下降（P<0.05），姑息術後血清TGF-α濃度與術前濃度無差異（P>0.05）。結論結直腸癌患者血清TGF-α濃度可作為判斷結直腸癌噁性程度和腫瘤是否根治的一項臨床指標。
목적：탐토검측혈흡충병결직장암전화생장인자-α혈청농도적림상의의。방법대2009년7월-2012년7월인만성복사혹반유혈편혹점액편，래아원주장경검사증실위혈흡충병결직장암적48례환자（시험조）술전、술후주혈청전화생장인자-α（TGF-α）측정，병이동기인만성복사주장경검사증실위만성혈흡충병결직장염환자40례（대조조）적혈청TGF-α진행대비，2조환자균채용매련면역흡부시험진행검측。결과혈흡충병결직장암환자적혈청TGF-α농도（296±99）pg/mL교혈흡충병결장염환자고（167±28）pg/mL （P<0.01）。결직장암환자적혈청TGF-α농도여종류분기、종류대소무관（P>0.05），여종류조직학분류정정상관（P<0.05），근치술후혈청TGF-α농도교술전명현하강（P<0.05），고식술후혈청TGF-α농도여술전농도무차이（P>0.05）。결론결직장암환자혈청TGF-α농도가작위판단결직장암악성정도화종류시부근치적일항림상지표。
Objective To study the clinical signification of detecting serum levels of transforming Growth factor-α(TGF-α) in schistosomiasis patients with colorectal cancer. Methods Forty-eight schistosomiasis patients with colorectal cancer accompanying chronic colorectal inflammation or hematochezia or mucous stool were found by colonoscopy in our hospital from July, 2009 to July, 2012,they (as the study group) measured serum levels transforming Growth factor-α,preoperatively or postoperatively, forty schistosomiasis patients with chronic diarrhea were found by colonoscopy(as the control group) measured serum levels of TGF-αsimultaneously. Result The serum levels of TGF-α(296±99 pg/mL)in schistosomiasis patients with colorectal cancer were significantly higher than in the schistosomiasis patients with chronic colorectal inflammation (167±28 pg/mL. The serum levels of TGF-αin patients with colorectal cancer is not related to the tumor stage and the tumor size (P>0.05), and is related to histologic grade (P<0.05). The serum levels of TGF-αbefore surgery significantly decreased after radical surgical resection of tumors (P<0.05) and not decreased after palliative surgical resection of tumor (P>0.05). Conclusion The serum levels of TGF-αcan act as a clinical index judging the hostologic grade and radical resection of tumors.
