CAJ | 학술논문

目的：探讨侵袭性纤维瘤病的临床、病理、影像学特征及治疗方法。方法报告1例腹壁侵袭性纤维瘤病病例，结合文献探讨该病的临床特点、影像学特征、病理学表现、治疗及预后。结果侵袭性纤维瘤病在临床上较为少见，表现为向周围组织侵袭生长的包块，无包膜，界限不清，活动度差。影像学检查无特异性，难以与其他软组织肿瘤相鉴别。病理学特点：主要由梭形的纤维母细胞和肌纤维母细胞呈束状排列，无明显异型性，核分裂象少。本病易复发，手术治疗应彻底，放疗对肿瘤局部控制及降低复发率有一定作用，同时还有化疗和内分泌等治疗方法。结论侵袭性纤维瘤病是一种局部侵袭性较强的病变，应结合临床表现、CT、MRI及病理学特点诊断本病。治疗关键为首次手术切除范围需广泛，切缘距瘤缘3 cm以上，使切缘完全阴性。放疗可局部控制肿瘤生长及降低复发率。
목적：탐토침습성섬유류병적림상、병리、영상학특정급치료방법。방법보고1례복벽침습성섬유류병병례，결합문헌탐토해병적림상특점、영상학특정、병이학표현、치료급예후。결과침습성섬유류병재림상상교위소견，표현위향주위조직침습생장적포괴，무포막，계한불청，활동도차。영상학검사무특이성，난이여기타연조직종류상감별。병이학특점：주요유사형적섬유모세포화기섬유모세포정속상배렬，무명현이형성，핵분렬상소。본병역복발，수술치료응철저，방료대종류국부공제급강저복발솔유일정작용，동시환유화료화내분비등치료방법。결론침습성섬유류병시일충국부침습성교강적병변，응결합림상표현、CT、MRI급병이학특점진단본병。치료관건위수차수술절제범위수엄범，절연거류연3 cm이상，사절연완전음성。방료가국부공제종류생장급강저복발솔。
Objective To study on clinical, pathological, radiological feature and treatment of the aggressive fibromatosis (AF).Methods A case with aggressive fibromatosis was reported,while the discase's clinical feature, radiological findings,pathological character,treatment and prognosis were reviewed in the literatures. Results AF is a rare tumor, which was characterized with infiltrative growth, low metastasis rate and high recurrence rate after an incomplete local resection. Iconography is a lock of characteristic, hardly distinguished AF from other soft tissue neoplasms. Microscopically,AF is composed of slender fibroblasts and myofibroblasts within cellagen, a lock of mitotic figures and nuclear atypia. The disease has the polarity of recurrence,en bloc resection and radiotherapy may decrease the local recurrence rate after operation. Chemotherapy, endocrine and targeted therapy may offer a cure. Conclusion Aggressive fibromatosis is a highly invasive local aggressive lesion whose diagnosis results from clinical feature ,CT findings,MRI scans and pathological features. Complete resection is the key for the treatment of AF,and margin from tumor edge should be at least 3 cm above. Meanwhile the radiotherapy may reduce recurrence.