中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
5期
472-474
,共3页
亚胺培南%鲍曼不动杆菌%重症监护室%多重耐药
亞胺培南%鮑曼不動桿菌%重癥鑑護室%多重耐藥
아알배남%포만불동간균%중증감호실%다중내약
Imipenem%Acinetobacter baumannii%Intensive care unit%Multiple drug resistance
目的 了解对亚胺培南耐药的鲍曼不动杆菌(IRAB)的分布特点及耐药性.方法 回顾性对比分析517株IRAB和319株对亚胺培南非耐药的鲍曼不动杆菌(非IRAB)分布和耐药率;细菌鉴定和药敏试验采用VITEK 2 Compact全自动细菌培养鉴定仪.结果 IRAB的检出率为61.8％(517/836);IRAB主要标本来源为痰液85.5％(442/517);IRAB中主要病区的构成比:ICU占55.9％(289/517),而非IRAB中ICU只占7.8％(25/517);IRAB对阿米卡星耐药率较低(27.2％,26/317);阿米卡星和哌拉西林/他唑巴坦对非IRAB的抗菌活性较好,耐药率分别为8.0％(21/262),8.2％(26/317);除头孢唑啉、头孢替坦、复方新诺明、呋喃妥因外,余抗菌药物的耐药率IRAB明显高于非IRAB,差异有统计学意义(P均＜0.05).结论 IRAB在ICU的检出率和耐药性较高,应加强耐药性监测,采取联合治疗和相关的干预措施,有效控制IRAB的感染及流行.
目的 瞭解對亞胺培南耐藥的鮑曼不動桿菌(IRAB)的分佈特點及耐藥性.方法 迴顧性對比分析517株IRAB和319株對亞胺培南非耐藥的鮑曼不動桿菌(非IRAB)分佈和耐藥率;細菌鑒定和藥敏試驗採用VITEK 2 Compact全自動細菌培養鑒定儀.結果 IRAB的檢齣率為61.8％(517/836);IRAB主要標本來源為痰液85.5％(442/517);IRAB中主要病區的構成比:ICU佔55.9％(289/517),而非IRAB中ICU隻佔7.8％(25/517);IRAB對阿米卡星耐藥率較低(27.2％,26/317);阿米卡星和哌拉西林/他唑巴坦對非IRAB的抗菌活性較好,耐藥率分彆為8.0％(21/262),8.2％(26/317);除頭孢唑啉、頭孢替坦、複方新諾明、呋喃妥因外,餘抗菌藥物的耐藥率IRAB明顯高于非IRAB,差異有統計學意義(P均＜0.05).結論 IRAB在ICU的檢齣率和耐藥性較高,應加彊耐藥性鑑測,採取聯閤治療和相關的榦預措施,有效控製IRAB的感染及流行.
목적 료해대아알배남내약적포만불동간균(IRAB)적분포특점급내약성.방법 회고성대비분석517주IRAB화319주대아알배남비내약적포만불동간균(비IRAB)분포화내약솔;세균감정화약민시험채용VITEK 2 Compact전자동세균배양감정의.결과 IRAB적검출솔위61.8％(517/836);IRAB주요표본래원위담액85.5％(442/517);IRAB중주요병구적구성비:ICU점55.9％(289/517),이비IRAB중ICU지점7.8％(25/517);IRAB대아미잡성내약솔교저(27.2％,26/317);아미잡성화고랍서림/타서파탄대비IRAB적항균활성교호,내약솔분별위8.0％(21/262),8.2％(26/317);제두포서람、두포체탄、복방신낙명、부남타인외,여항균약물적내약솔IRAB명현고우비IRAB,차이유통계학의의(P균＜0.05).결론 IRAB재ICU적검출솔화내약성교고,응가강내약성감측,채취연합치료화상관적간예조시,유효공제IRAB적감염급류행.
Objective To investigate the distribution of the Bauman acinetobacter baumannii (IRAB) resisted to imipenem and character of drug resistance.Methods Retrospective analyzed 517 strains of IRAB and 319 strains of imipenem drug resistance of acinetobacter baumannii from South Africa (not IRAB) by VITEK 2 compact automatic bacterial culture identification.Results IRAB positive rate was 61.8％ (517/836).The main source of IRAB was from sputum(85.5％ (442/517)).The constitute ratio of main areas in IRAB was ICU ward (55.9％) and only 7.8％ in non-IRAB.The resistant rate of IRAB to amikacin was 27.2％.The resistant rate of non-IRAB to Amikacin and piperacillin/tazobactam were 8.0％ (21/262),8.2％ (26/317),suggesting the good antibacterial activity.In terms of rate of resistance drug,apart from Cefazolin,Cefotetan,Cotrimoxazole,Nitrofurantoin,the sort of antibacterial drugs against IRAB was obviously higher than that of non-IRAB,and difference was statistically significant (P ＜ 0.05).Conclusion Drug resistance surveillance should be strengthened because of high detection rate and drug resistance in ICU in terms of IRAB.Combination therapy and related intervention measures might effective control of infection and IRAB.
