癌变·畸变·突变
癌變·畸變·突變
암변·기변·돌변
CARCINOGENSES,TERATOGENSIS AND MUTAGENESIS
2014年
1期
20-23
,共4页
张彤彤%梁建伟%王征%张钰%刘一臻%商利%杨海%蔡岩%徐昕%王明荣
張彤彤%樑建偉%王徵%張鈺%劉一臻%商利%楊海%蔡巖%徐昕%王明榮
장동동%량건위%왕정%장옥%류일진%상리%양해%채암%서흔%왕명영
Cortactin%结直肠癌%免疫组织化学%预后
Cortactin%結直腸癌%免疫組織化學%預後
Cortactin%결직장암%면역조직화학%예후
Cortactin%colorectal cancer%immunohistochemistry%prognosis
目的：探讨Cortactin(CTTN)蛋白在结直肠癌组织中的表达变化及其临床意义。方法：采用免疫组织化学法检测100例结直肠癌组织和癌旁正常组织中CTTN蛋白的表达情况，分析CTTN蛋白的表达变化与结直肠癌患者临床病理指标及预后的关系。结果：CTTN蛋白在结直肠癌组织中的阳性表达率为58%，显著高于癌旁正常组织的6%(P＜0.01)。CTTN蛋白(＜0.05)阳性表达率在不同的T分期(浸润深度)间的差异有统计学意义，而与患者的性别、年龄、肿瘤原发部位、肿瘤大小和淋巴结转移均无显著相关(P＞0.05)。生存分析的结果显示，CTTN阳性患者的预后差于CTTN阴性患者(P=0.014)。结论：CTTN蛋白在结直肠癌中表达增加，并与结直肠肿瘤的浸润深度有关，可能作为结直肠癌预后判断的指标。P
目的：探討Cortactin(CTTN)蛋白在結直腸癌組織中的錶達變化及其臨床意義。方法：採用免疫組織化學法檢測100例結直腸癌組織和癌徬正常組織中CTTN蛋白的錶達情況，分析CTTN蛋白的錶達變化與結直腸癌患者臨床病理指標及預後的關繫。結果：CTTN蛋白在結直腸癌組織中的暘性錶達率為58%，顯著高于癌徬正常組織的6%(P＜0.01)。CTTN蛋白(＜0.05)暘性錶達率在不同的T分期(浸潤深度)間的差異有統計學意義，而與患者的性彆、年齡、腫瘤原髮部位、腫瘤大小和淋巴結轉移均無顯著相關(P＞0.05)。生存分析的結果顯示，CTTN暘性患者的預後差于CTTN陰性患者(P=0.014)。結論：CTTN蛋白在結直腸癌中錶達增加，併與結直腸腫瘤的浸潤深度有關，可能作為結直腸癌預後判斷的指標。P
목적：탐토Cortactin(CTTN)단백재결직장암조직중적표체변화급기림상의의。방법：채용면역조직화학법검측100례결직장암조직화암방정상조직중CTTN단백적표체정황，분석CTTN단백적표체변화여결직장암환자림상병리지표급예후적관계。결과：CTTN단백재결직장암조직중적양성표체솔위58%，현저고우암방정상조직적6%(P＜0.01)。CTTN단백(＜0.05)양성표체솔재불동적T분기(침윤심도)간적차이유통계학의의，이여환자적성별、년령、종류원발부위、종류대소화림파결전이균무현저상관(P＞0.05)。생존분석적결과현시，CTTN양성환자적예후차우CTTN음성환자(P=0.014)。결론：CTTN단백재결직장암중표체증가，병여결직장종류적침윤심도유관，가능작위결직장암예후판단적지표。P
OBJECTIVE:To investigate the alteration of cortactin (CTTN) expression in colorectal cancer (CRC) and its correlation with clinico-pathological characteristics and prognosis. METHODS:Immunohistochemistry method was used to detect the expression of CTTN in 100 cases of CRC and adjacent normal tissues. The relationship between CTTN expression and clinico-pathological features and prognosis of the patients was evaluated. RESULTS:Positive rate of CTTN expression in colorectal cancer tissues was significantly higher than that in adjacent normal tissues (P<0.01). Expression of CTTN was correlated with depth of tumor invasion (P=0.037). A Kaplan-Meier survival analysis revealed that the patients with CTTN expression had a shorter overall survival (OS) than those with negative CTTN (P=0.014). CONCLUSION:CTTN overexpression was a common event,and seemed to be a poor prognostic factor for colorectal cancer.
