CAJ | 학술논문

目的：研究电针不同介入时间对大鼠脑出血（ ICH）的干预作用。方法：192只SD大鼠随机分为正常组、假手术组、模型组和电针组，各组分别分6 h、24 h、72 h、7 d共4个亚组。建立大鼠ICH模型，干预后评定行为学变化，并观察各组大鼠脑组织形态学改变。结果：大鼠灌注取脑前进行行为学评分，各组结果无统计学意义（P＞0．05）；光镜下：模型组血肿周围脑组织坏死，可见到较多含铁血黄素颗粒，炎细胞浸润。针刺组较模型组脑组织有所修复，其中6h组较其它各电针组改善更明显。结论：不同时间介入电针，特别是ICH后早期进行电针治疗，可以改善ICH大鼠脑组织损伤，减轻炎症反应，保护神经元，促进脑组织的功能修复。
목적：연구전침불동개입시간대대서뇌출혈（ ICH）적간예작용。방법：192지SD대서수궤분위정상조、가수술조、모형조화전침조，각조분별분6 h、24 h、72 h、7 d공4개아조。건립대서ICH모형，간예후평정행위학변화，병관찰각조대서뇌조직형태학개변。결과：대서관주취뇌전진행행위학평분，각조결과무통계학의의（P＞0．05）；광경하：모형조혈종주위뇌조직배사，가견도교다함철혈황소과립，염세포침윤。침자조교모형조뇌조직유소수복，기중6h조교기타각전침조개선경명현。결론：불동시간개입전침，특별시ICH후조기진행전침치료，가이개선ICH대서뇌조직손상，감경염증반응，보호신경원，촉진뇌조직적공능수복。
Objective:To study the intervention after experimental intracerebral hemorrhage ( ICH) in rats trea-ted by the electro-acupuncture ( EA) at different time points .Methods:192 rats were divided into normal con-trol group,sham operated group,ICH model group and EA group .Every group was divided into 6 h,24 h,72 h and 7 d subgroups .Produce the ICH models , evaluate the behavioral changes and observe the change of each rat's brain tissue appearance after the intervention .Results:Evaluate the behavioral changes before killing all the rats,there was no statistical significance between the subgroups ( P>0.05 );it was discovered that the model rat's brain tissue surrounding the hematoma was necrosis , containing lots of hemosiderin particles , phlegmasia cells infiltrated with the method of observation under light microscope .Compared with the model group ,the EA rats'damage was abatement , especially in the 6 h subgroup .Conclusion:The EA treatment at different time points ,especially the 6 h subgroups ,can lessen the dropsy of the brain tissue ,lighten the inflammatory reaction , protect the nerve cells and promote the function recovery of the brain tissue .