中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2014年
2期
300-301
,共2页
卡培他滨%三维适形放疗%老年中晚期食管癌%临床疗效%生活质量
卡培他濱%三維適形放療%老年中晚期食管癌%臨床療效%生活質量
잡배타빈%삼유괄형방료%노년중만기식관암%림상료효%생활질량
Capecitabine%Three dimensional conformal radiation therapy%Elderly middle and advanced esophageal cancer%Clinical effect%Quality of life
目的：探讨卡培他滨联合三维适形放射治疗(放疗)治疗老年中晚期食管癌的临床疗效。方法：选取我院2008~2013年70例老年中晚期食管癌患者的资料，随机分为观察组及对照组，各35例，所有患者均给予卡培他滨化疗，连续治疗2个周期，观察组在化疗的同时给予三维适形放疗，采用欧洲癌症研究与治疗组织调查问卷对患者生活质量进行评价，对两组患者的临床疗效、生活质量及不良反应进行比较。结果：观察组患者临床总有效率高于对照组，比较差异有统计学意义(P<0.05)；两组患者在恶心、呕吐、骨髓抑制等方面比较无明显差异，无统计学意义(P>0.05)；观察组患者生活质量评分优于对照组，比较差异明显，有统计学意义(P<0.05)。结论：卡培他滨联合三维适形放疗治疗老年中晚期食管癌，可提高患者近期疗效，不增加患者放疗毒副作用，治疗耐受性好，值得在临床推广。
目的：探討卡培他濱聯閤三維適形放射治療(放療)治療老年中晚期食管癌的臨床療效。方法：選取我院2008~2013年70例老年中晚期食管癌患者的資料，隨機分為觀察組及對照組，各35例，所有患者均給予卡培他濱化療，連續治療2箇週期，觀察組在化療的同時給予三維適形放療，採用歐洲癌癥研究與治療組織調查問捲對患者生活質量進行評價，對兩組患者的臨床療效、生活質量及不良反應進行比較。結果：觀察組患者臨床總有效率高于對照組，比較差異有統計學意義(P<0.05)；兩組患者在噁心、嘔吐、骨髓抑製等方麵比較無明顯差異，無統計學意義(P>0.05)；觀察組患者生活質量評分優于對照組，比較差異明顯，有統計學意義(P<0.05)。結論：卡培他濱聯閤三維適形放療治療老年中晚期食管癌，可提高患者近期療效，不增加患者放療毒副作用，治療耐受性好，值得在臨床推廣。
목적：탐토잡배타빈연합삼유괄형방사치료(방료)치료노년중만기식관암적림상료효。방법：선취아원2008~2013년70례노년중만기식관암환자적자료，수궤분위관찰조급대조조，각35례，소유환자균급여잡배타빈화료，련속치료2개주기，관찰조재화료적동시급여삼유괄형방료，채용구주암증연구여치료조직조사문권대환자생활질량진행평개，대량조환자적림상료효、생활질량급불량반응진행비교。결과：관찰조환자림상총유효솔고우대조조，비교차이유통계학의의(P<0.05)；량조환자재악심、구토、골수억제등방면비교무명현차이，무통계학의의(P>0.05)；관찰조환자생활질량평분우우대조조，비교차이명현，유통계학의의(P<0.05)。결론：잡배타빈연합삼유괄형방료치료노년중만기식관암，가제고환자근기료효，불증가환자방료독부작용，치료내수성호，치득재림상추엄。
Objectives:To investigate the clinical effects of capecitabine combined with Three dimensional conformal radiation therapytherapy on elderly middle or advanced esophageal cancer patients.Methods:Seventy patients of elderly middle or advanced esophageal cancer hospitalizing in our clinic were collected from 2008 to 2013.All the cases,assigned randomly into observation group or control group and each group had thirty-five,were treated with capecitabine for 2 cycles and Three dimensional conformal radiation therapytherapy was performed on observation group.The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) was employed on the evaluation of patients' life quality.The clinical efficacy,quality of life and adverse reaction were compared between the two groups.Results:The total clinical effective rate in observation group was higher than that in control group.The difference was statistically significant (P<0.05).No significant differences were observed between the two groups in nausea,vomit and myelosuppression (P>0.05).The quality of life in the observation group was superior to control group.The difference was statistically significant (P<0.05).Conclusion:Capecitabine combined with Three dimensional conformal radiation therapytherapy had potential of promoting in clinical treatment of middle or advanced esophageal cancer in elderly patients for superior short-term effects and tolerance.
