CAJ | 학술논문

目的：探讨阿维A辅助治疗复发性尖锐湿疣临床效果及安全性。方法选取本院近年来收治复发性尖锐湿疣患者70例，随机分为对照组和阿维A组，每组各35例；其中对照组采用常规对症治疗；阿维A组在对照组治疗基础上，加用阿维A口服治疗；比较两组患者临床复发率，治疗前后血清细胞因子水平及不良反应发生率等。结果阿维A组患者治疗后1个月、3个月及6个月临床复发率均显著低于对照组（ P＜0.05）；对照组和阿维A组患者治疗后IL-4、IL-10及IFN-γ等细胞因子水平均显著优于治疗前，且阿维A组患者细胞因子水平改善程度均显著优于于对照组（ P＜0.05）；阿维A组患者皮肤不适及口干发生率均显著高于对照组，但皮肤溃烂发生率显著低于对照组（P＜0.05）。结论阿维A辅助治疗复发性尖锐湿疣可有效降低临床复发风险，改善机体细胞因子水平，提高机体免疫力，且无严重不良反应。
목적：탐토아유A보조치료복발성첨예습우림상효과급안전성。방법선취본원근년래수치복발성첨예습우환자70례，수궤분위대조조화아유A조，매조각35례；기중대조조채용상규대증치료；아유A조재대조조치료기출상，가용아유A구복치료；비교량조환자림상복발솔，치료전후혈청세포인자수평급불량반응발생솔등。결과아유A조환자치료후1개월、3개월급6개월림상복발솔균현저저우대조조（ P＜0.05）；대조조화아유A조환자치료후IL-4、IL-10급IFN-γ등세포인자수평균현저우우치료전，차아유A조환자세포인자수평개선정도균현저우우우대조조（ P＜0.05）；아유A조환자피부불괄급구간발생솔균현저고우대조조，단피부궤란발생솔현저저우대조조（P＜0.05）。결론아유A보조치료복발성첨예습우가유효강저림상복발풍험，개선궤체세포인자수평，제고궤체면역력，차무엄중불량반응。
Objective To investigate clinical efficacy and security of Avi A associated treatment on re -current genital warts .Methods 70 patients with recurrent genital warts were chosen in recent years in our hos-pital and randomly divided into two groups including control group (35 patients) with conventional symptomatic treatment and Avi A group (35 patients) with Avi A orally treatment;and the clinical relapse rate , cytokines levels in serum before and after treatment and incidence of adverse reaction of both groups were compared . Results The clinical relapse rate of Avi A group was lower than control group in 1 month, 3 months and 6 months after treatment(P<0.05).The cytokines levels in serum after treatment of both groups was significant better than before treatment(P<0.05).The improving degree of Avi A group after treatnemtn was significant higher than control group ( P<0.05 ) .The incidence of skin irritation , dry mouth of Avi A group was higher than control group(P<0.05).The incidence of skin ulcers of Avi A group was lower than control group (P<0.05).Conclusion Avi A associated treatment on recurrent genital warts can efficiently reduce the risk of clinical recurrence , improve cytokines levels , higher body immunity , and has no serious adverse reactions .