中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2014年
2期
9-10
,共2页
食管肿瘤%人乳头状瘤病毒%E6蛋白%免疫组化
食管腫瘤%人乳頭狀瘤病毒%E6蛋白%免疫組化
식관종류%인유두상류병독%E6단백%면역조화
Esophageal neoplasm%Human Papillomavirus ( HPV)%E6 protein%Immunohistochemistry
目的:通过分析HPV16-E6蛋白在食管正常组织、不典型性增生组织和癌组织中的表达,探讨HPV16-E6蛋白在梅州地区客家人食管鳞癌组发生、发展中的生物学意义。方法应用免疫组织化学方法检测对68例食管正常黏膜组织、20例上皮不典型增生组织及68例癌组织中HPV16-E6蛋白的表达情况进行研究。结果 HPV16-E6蛋白阳性率在正常食管黏膜组织中为14.7%,在上皮不典型性增生组织中为45.0%,在癌组织中为70.6%,各组间差异有统计学意义( P<0.05)。结论 HPV16-E6蛋白与梅州地区客家人食管鳞癌的发生、发展关系密切。
目的:通過分析HPV16-E6蛋白在食管正常組織、不典型性增生組織和癌組織中的錶達,探討HPV16-E6蛋白在梅州地區客傢人食管鱗癌組髮生、髮展中的生物學意義。方法應用免疫組織化學方法檢測對68例食管正常黏膜組織、20例上皮不典型增生組織及68例癌組織中HPV16-E6蛋白的錶達情況進行研究。結果 HPV16-E6蛋白暘性率在正常食管黏膜組織中為14.7%,在上皮不典型性增生組織中為45.0%,在癌組織中為70.6%,各組間差異有統計學意義( P<0.05)。結論 HPV16-E6蛋白與梅州地區客傢人食管鱗癌的髮生、髮展關繫密切。
목적:통과분석HPV16-E6단백재식관정상조직、불전형성증생조직화암조직중적표체,탐토HPV16-E6단백재매주지구객가인식관린암조발생、발전중적생물학의의。방법응용면역조직화학방법검측대68례식관정상점막조직、20례상피불전형증생조직급68례암조직중HPV16-E6단백적표체정황진행연구。결과 HPV16-E6단백양성솔재정상식관점막조직중위14.7%,재상피불전형성증생조직중위45.0%,재암조직중위70.6%,각조간차이유통계학의의( P<0.05)。결론 HPV16-E6단백여매주지구객가인식관린암적발생、발전관계밀절。
Objective To explore the biological significance of HPV 16-E6 in the esophageal squamous cell carcinogenesis of Meizhou Hakka People through determining the expression of HPV 16-E6 protein in normal tissues, dysplasia tissues and carcinoma tissues of esophagus .Methods Immunohistochemistry technique was used to detect the expression of the HPV 16-E6 protein in 68 cases of normal tissues , 20 cases of dysplasia tis-sues and 68 cases of carcinoma tissues of esophagus .Results The positive rates of HPV16-E6 protein in the tissues of normal mucosa ,dysplasia and carcinoma of esophagus patients were 14.7%, 45.0%and 70.6%re-spectively .There was significantly difference among the three groups respectively ( P<0.05 ) .Conclusion HPV16-E6 protein are highly associated with esophageal squamous cell carcinogenesis of Meizhou Hakka Peo -ple.