CAJ | 학술논문

目的：探讨维格列汀联合二甲双胍治疗2型糖尿病的临床疗效及安全性。方法选取2010年10月-2012年10月收治的2型糖尿病患者120例，随机分为2组，每组60例。对照组予二甲双胍治疗，治疗组予二甲双胍联合维格列汀进行治疗，对比2组患者的临床疗效及不良反应。结果与治疗前比较，治疗后2组HbA1c、FPG、2hPG、INS均明显降低、GLP-1水平升高（ P均＜0．01），且治疗组较对照组HbA1c、FPG、INS降低，而GLP-1水平升高更明显（ P均＜0．01）。2组均未发生不良反应。结论二甲双胍联合维格列汀治疗2型糖尿病，临床疗效优于单独使用二甲双胍，且在增加疗效的同时未发现不良反应，具有较高的临床应用价值。
목적：탐토유격렬정연합이갑쌍고치료2형당뇨병적림상료효급안전성。방법선취2010년10월-2012년10월수치적2형당뇨병환자120례，수궤분위2조，매조60례。대조조여이갑쌍고치료，치료조여이갑쌍고연합유격렬정진행치료，대비2조환자적림상료효급불량반응。결과여치료전비교，치료후2조HbA1c、FPG、2hPG、INS균명현강저、GLP-1수평승고（ P균＜0．01），차치료조교대조조HbA1c、FPG、INS강저，이GLP-1수평승고경명현（ P균＜0．01）。2조균미발생불량반응。결론이갑쌍고연합유격렬정치료2형당뇨병，림상료효우우단독사용이갑쌍고，차재증가료효적동시미발현불량반응，구유교고적림상응용개치。
Objective To investigate the clinical efficacy of vildagliptin metformin in the treatment of type 2 diabetes and security analysis .Methods Selected from October, 2010 to October, 2012 admitted 120 patients with type 2 diabetes, they were randomly divided into 2 groups with each group of 60cases .In the control group , patients received metformin , treat-ment group were treated with metformin and vildagliptin , compared two groups of patients with clinical efficacy and adverse re-actions.Results Compared with before treatment, after treatment, two groups HbA1c, FPG, 2hPG, INS were significantly lower, and with elevated levels of GLP-1 ( P <0.01), and the treatment group compared with the control group , HbA1c, FPG, INS reduced, while GLP-1 levels increased more significantly ( P <0.01).2 groups were found no adverse reactions . Conclusion Metformin combined with vildagliptin in the treatment of type 2 diabetes , the clinical efficacy is superior to met-formin alone, and found no increase in adverse effects , while having a high clinical value .